TRPC channels in exercise-mimetic therapy.
TRPC channels in exercise-mimetic therapy.
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DOI：
10.1007/s00424-018-2211-3
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Nishida M
中科院分区：
文献类型：
--
作者：
Numaga-Tomita T;Oda S;Nishiyama K;Tanaka T;Nishimura A;Nishida M
体育锻炼对所有类型的肌肉细胞产生有益的影响，这些细胞对于维持心血管稳态和良好的血液循环至关重要。每天适度的运动可以增加全身的抗氧化能力，从而预防氧化应激相关疾病的发生和发展。因此，运动现在被广泛接受为治疗缺血性（缺氧性）疾病的最佳治疗策略之一。经典瞬时受体电位（TRPC）蛋白是由机械应力和/或磷脂酶C偶联表面受体刺激激活的非选择性阳离子通道。TRPC通道，特别是二酰基甘油激活的TRPC通道（TRPC 3和TRPC 6; TRPC 3/6），在心血管重构的发展中起关键作用。我们最近发现，TRPC 3和NADPH氧化酶（Nox）2之间的物理相互作用，在低氧应激下促进Nox 2依赖性活性氧（ROS）的生产和介导啮齿动物心脏的可塑性，和TRPC 3-Nox 2蛋白复合物的抑制导致心肌顺应性和灵活性的增强，类似于在运动治疗的心脏中观察到的。在这篇综述中，我们描述了TRPC通道在横纹肌（病理）生理学中的作用，并提出靶向基于TRPC的蛋白质复合物可能是一种新的策略，以模仿运动疗法。
Physical exercise yields beneficial effects on all types of muscle cells, which are essential for the maintenance of cardiovascular homeostasis and good blood circulation. Daily moderate exercise increases systemic antioxidative capacity, which can lead to the prevention of the onset and progression of oxidative stress-related diseases. Therefore, exercise is now widely accepted as one of the best therapeutic strategies for the treatment of ischemic (hypoxic) diseases. Canonical transient receptor potential (TRPC) proteins are non-selective cation channels activated by mechanical stress and/or stimulation of phospholipase C-coupled surface receptors. TRPC channels, especially diacylglycerol-activated TRPC channels (TRPC3 and TRPC6; TRPC3/6), play a key role in the development of cardiovascular remodeling. We have recently found that physical interaction between TRPC3 and NADPH oxidase (Nox) 2 under hypoxic stress promotes Nox2-dependent reactive oxygen species (ROS) production and mediates rodent cardiac plasticity, and inhibition of the TRPC3-Nox2 protein complex results in enhancement of myocardial compliance and flexibility similar to that observed in exercise-treated hearts. In this review, we describe current understanding of the roles of TRPC channels in striated muscle (patho)physiology and propose that targeting TRPC-based protein complexes could be a new strategy to imitate exercise therapy.
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影响因子：
4.6
作者：
Kitajima N;Numaga-Tomita T;Watanabe M;Kuroda T;Nishimura A;Miyano K;Yasuda S;Kuwahara K;Sato Y;Ide T;Birnbaumer L;Sumimoto H;Mori Y;Nishida M
通讯作者：
Nishida M
影响因子：
4
作者：
Henríquez-Olguín C;Díaz-Vegas A;Utreras-Mendoza Y;Campos C;Arias-Calderón M;Llanos P;Contreras-Ferrat A;Espinosa A;Altamirano F;Jaimovich E;Valladares DM
通讯作者：
Valladares DM
影响因子：
--
作者：
Ashrafi, Javad;Roshan, Valiollah Dabidi
通讯作者：
Roshan, Valiollah Dabidi
影响因子：
5.5
作者：
Jackson, Malcolm J.;McArdle, Anne
通讯作者：
McArdle, Anne
影响因子：
4
作者：
Formigli, Lucia;Sassoli, Chiara;Meacci, Elisabetta
通讯作者：
Meacci, Elisabetta