Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway.
Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway.
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DOI：
10.1038/ncomms9521
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发表时间：
2015-10-12
影响因子：
16.6
通讯作者：
Ponomarenko A
中科院分区：
文献类型：
--
作者：
Bender F;Gorbati M;Cadavieco MC;Denisova N;Gao X;Holman C;Korotkova T;Ponomarenko A
海马体θ波振荡支持动物在空间导航过程中的位置编码，但关于它们对运动的影响的长期问题仍未得到解答。结合光遗传学对小鼠海马θ波振荡的控制和电生理记录，我们发现海马θ波振荡调节运动。特别是，我们证明了它们的规律性是在探索过程中更稳定和更慢的运行速度的基础。更有规律的θ波振荡伴随着锥体细胞更有规律的θ节奏尖峰输出。Theta振荡在海马和它的主要皮层下输出，侧隔（LS）之间协调。化学或光遗传抑制这一途径揭示了其对海马调节跑步速度的必要性。此外，对下丘脑外侧的LS投影的节律性刺激复制了更规律的海马θ振荡引起的跑步速度降低。这些结果表明，海马theta同步的变化通过LS转化为跑步速度的快速调整。海马体θ波振荡支持导航过程中的空间信息编码，但其在运动中的作用尚不清楚。在这里，作者证明了海马θ波振荡通过海马-外侧隔-下丘脑通路调节啮齿动物的运动速度。
Hippocampal theta oscillations support encoding of an animal's position during spatial navigation, yet longstanding questions about their impact on locomotion remain unanswered. Combining optogenetic control of hippocampal theta oscillations with electrophysiological recordings in mice, we show that hippocampal theta oscillations regulate locomotion. In particular, we demonstrate that their regularity underlies more stable and slower running speeds during exploration. More regular theta oscillations are accompanied by more regular theta-rhythmic spiking output of pyramidal cells. Theta oscillations are coordinated between the hippocampus and its main subcortical output, the lateral septum (LS). Chemo- or optogenetic inhibition of this pathway reveals its necessity for the hippocampal regulation of running speed. Moreover, theta-rhythmic stimulation of LS projections to the lateral hypothalamus replicates the reduction of running speed induced by more regular hippocampal theta oscillations. These results suggest that changes in hippocampal theta synchronization are translated into rapid adjustment of running speed via the LS. Hippocampal theta oscillations support encoding of spatial information during navigation, yet their role in locomotion is poorly understood. Here the authors demonstrate that hippocampal theta oscillations regulate the speed of locomotion in rodents through a hippocampo-lateral septal-hypothalamic pathway.