Associations between circulating sex steroid hormones and cognition in normal elderly women
Associations between circulating sex steroid hormones and cognition in normal elderly women
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DOI：
10.1212/wnl.54.3.599
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发表时间：
2000-02-08
期刊：
影响因子：
9.9
通讯作者：
Buckwalter, JG
中科院分区：
文献类型：
--
作者：
Drake, EB;Henderson, VW;Buckwalter, JG
目的：探讨老年妇女几种性激素水平与认知能力的关系。背景：性类固醇激素与成人大脑的认知过程有关。通过比较不同激素水平（如月经周期、手术停经和雌激素替代疗法）对认知能力的影响，发现雌激素水平较高的女性有更好的言语记忆和更差的视觉空间能力。方法：作者测量了39名高学历、无痴呆、主要是白人老年妇女的循环性激素水平。水平与神经心理表现相关，控制年龄、教育程度、先前检测频率、使用雌激素替代和抑郁。结果：高雌二醇水平与较好的延迟言语记忆和检索效率相关，而低雌二醇水平与较好的即时和延迟视觉记忆相关。睾丸激素水平与语言流畅度呈正相关。黄体酮和雄烯二酮的水平与认知能力无关。结论：雌激素和睾酮均与认知能力有关。雌激素可以增强或抑制特定的认知能力。
Objective: To provide exploratory analyses of associations between levels of several sex hormones and cognitive performance in elderly women. Background: Sex steroid hormones are implicated in the cognitive processes of the adult brain. Comparing cognitive performance across or between conditions associated with different hormone levels, such as phases of the menstrual cycle, surgical menopause, and estrogen replacement therapy suggests conditions with higher levels of estrogen are associated with better verbal memory and possibly worse visuospatial ability. Method: The authors measured circulating sex hormone levels in 39 highly educated, nondemented, predominantly white elderly women. Levels were correlated with neuropsychological performance, controlling for age, education, frequency of prior testing, use of estrogen replacement, and depression. Results, High estradiol levels were associated with better delayed verbal memory and retrieval efficiency, whereas low levels were associated with better immediate and delayed visual memory. Levels of testosterone were related positively to verbal fluency. Levels of progesterone and androstenedione were unrelated to cognitive performance. Conclusions: Both estrogen and testosterone showed associations with cognitive performance. Estrogen may enhance, and depress, specific cognitive skills.