Metformin As a Geroprotector
Metformin As a Geroprotector
复制标题
DOI：
10.1089/rej.2011.1153
复制
发表时间：
2011-10-01
影响因子：
2.6
通讯作者：
Bulterijs, Sven
中科院分区：
文献类型：
--
作者：
Bulterijs, Sven
老年保护剂是降低衰老速度从而延长寿命的药物。二甲双胍被描述为一种老年保护剂，多项研究表明二甲双胍可以减缓衰老速度。二甲双胍的老年保护作用背后的机制尚不明确。本次综述的目的是调查二甲双胍的老年保护作用的证据并描述其背后的可能机制。
Geroprotectors are drugs that decrease the rate of aging and therefore extend life span. Metformin has been described as a geroprotector, and several studies have shown that metformin can slow down the rate of aging. The mechanisms behind the geroprotective effect of metformin are less established. The goal of this review is to investigate the evidence for the geroprotective effect of metformin and to describe the possible mechanisms behind it.