Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in type 2 diabetes mellitus
Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in type 2 diabetes mellitus
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DOI：
10.1111/j.1600-051x.2008.01359.x
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发表时间：
2009-02-01
影响因子：
6.7
通讯作者：
Miyazaki, Hideo
中科院分区：
文献类型：
--
作者：
Matsumoto, Sayaka;Ogawa, Hiroshi;Miyazaki, Hideo
松本S，小川H，苏打S，平山S，Amarasena N，相泽Y，宫崎H. 2型糖尿病患者牙周抗菌治疗及维持对血清脂联素的影响。临床牙周病学杂志2009; 36：-.土井：10.1111/j.1600 - 051X.2008.01359.x.本研究的目的是评价局部应用米诺环素（APT）的机械牙周治疗对血清脂联素的影响，血清脂联素是2型糖尿病（T2DM）患者胰岛素抵抗改善的标志物，并研究APT对血清脂联素水平的影响是否通过牙周维护（PM）来维持。将27例T2DM患者随机分为试验组和对照组。试验组在基线时接受超声器械洁治，每两周接受一次APT，持续2个月;对照组在基线时接受洁治，每两周接受一次机械洁牙（MPT）。在6个月时，所有患者均接受机械牙齿清洁作为PM。分别于治疗前、治疗后4个月和治疗后9个月进行牙周检查和血液检测，结果显示：治疗后脂联素水平较治疗前显著升高31.4%（p = 0.024），治疗后脂联素水平较治疗前显著升高30.4%（p = 0.002）。在实验组中，APT和PM治疗后，牙周探诊深度（PD）>= 4 mm的百分比分别减少了8.3%和9.3%（p = 0.046，0.02），而对照组中，MPT治疗后PD减少了5.0%（p = 0.031）。我们的结果表明，APT和PM不仅改善了T2DM患者的牙周病，而且还增加了血清脂联素。
Matsumoto S, Ogawa H, Soda S, Hirayama S, Amarasena N, Aizawa Y, Miyazaki H. Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in Type 2 Diabetes Mellitus. J Clin Periodontol 2009; 36: -. doi: 10.1111/j.1600-051X.2008.01359.x.The aims of this study were to evaluate the effect of mechanical periodontal treatment with local application of minocycline (APT) on serum adiponectin as a marker of insulin resistance improvement in type 2 diabetes mellitus (T2DM) patients and to investigate if effect of APT on serum adiponectin level was sustained by periodontal maintenance (PM).Twenty-seven T2DM patients were randomly assigned into test or control groups. Test received scaling with ultrasonic devices at baseline and APT biweekly for 2 months while control received scaling at baseline and mechanical tooth cleaning (MPT) at the same interval. At 6 months, all patients received mechanical tooth cleaning as PM. Periodontal examination and blood measurements were performed at baseline, 4 and 9 months.Adiponectin concentrations in test had significantly increased by 31.4% after APT (p=0.024) and by 30.4% after PM (p=0.002) compared with baseline. The percentage of >= 4 mm probing depths (PD) had shown 8.3% and 9.3% reduction after APT and PM (p=0.046, 0.02) in test while 5.0% reduction after MPT in control group (p=0.031).Our results suggested that APT and PM not only improve periodontal disease but also increase serum adiponectin in T2DM patients.