Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002
Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002
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DOI：
10.1016/j.psyneuen.2019.03.012
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发表时间：
2019-08-01
影响因子：
3.7
通讯作者：
Belsky, Daniel W.
中科院分区：
文献类型：
--
作者：
Hastings, Waylon J.;Shalev, Idan;Belsky, Daniel W.
背景：衰老的生物学过程被认为是许多不同慢性疾病的可改变原因。生物衰老的测量可以为假设会缩短健康寿命的风险因素和/或延长健康寿命的干预措施的研究提供敏感的终点。但是，关于如何测量生物衰老，以及拟议的测量方法是否评估同样的事情，仍然存在不确定性。方法：我们测试了四种拟议的生物衰老测量方法，这些方法可以用来自国家健康和营养检查调查（NHANES）、klemera - double法（KDM）生物年龄、稳态失调、Levine法（LM）生物年龄和白细胞端粒长度的可用数据进行量化。结果：我们分析了1999-2002年期间收集的数据，当时可以采取所有四种生物老化措施。参与者的KDM生物年龄、体内平衡失调水平、LM生物年龄和端粒长度均与实足年龄相关。KDM生物年龄、体内平衡失调和LM生物年龄均相互相关，但这些指标与端粒长度无关。生物衰老程度越高的参与者在身体、认知和感知功能的测试中表现越差，他们的日常活动受到更多限制，感到更多疼痛，并认为自己的健康状况更差。与此同时，具有较短健康寿命风险因素的参与者表现出更严重的生物衰老。在这两组分析中，与端粒长度相比，KDM生物年龄、稳态失调和LM生物年龄的效应值往往更大。讨论：与患者水平生理复合指标KDM生物年龄、稳态失调和LM生物年龄相比，细胞水平衰老生物标志物端粒长度可以测量衰老过程的不同方面。旨在测试风险因素是否加速衰老或干预措施是否可能减缓衰老的研究不应将提出的衰老措施视为可互换的。
Background: Biological processes of aging are thought to be modifiable causes of many different chronic diseases. Measures of biological aging could provide sensitive endpoints for studies of risk factors hypothesized to shorten healthy lifespan and/or interventions that extend it. But uncertainty remains about how to measure biological aging and if proposed measures assess the same thing.Method: We tested four proposed measures of biological aging that could be quantified with available data from the National Health and Nutrition Examination Survey (NHANES), Klemera-Doubal method (KDM) Biological Age, homeostatic dysregulation, Levine Method (LM) Biological Age, and leukocyte telomere length.Results: We analyzed data collected during 1999-2002, when all four biological aging meausres could be taken. Participants' KDM biological ages, homeostatic dysregulation levels, LM biological ages, and telomere length were all correlated with their chronological ages. KDM Biological Age, homeostatic dysregulation, and LM Biological Age were all correlated with one another, but these measures were uncorrelated with telomere length. Participants' with more advanced biological aging performed worse on tests of physical, cognitive, and perceptual functioning and reported more limitations to their daily activities and more pain, and rated themselves as being in worse health. In parallel, participants with risk factors for shorter healthy lifespan exhibited more advanced biological aging. In both sets of analyses, effect-sizes tended to be larger for KDM Biological Age, homeostatic dysregulation, and LM Biological Age as compared to telomere length.Discussion: The cellular-level aging biomarker telomere length may measure different aspects of the aging process as compared to the patient-level physiological composite measures KDM Biological Age, homeostatic dysregulation, and LM Biological Age. Studies aiming to test if risk factors accelerate aging or if interventions may slow aging should not treat proposed measures of aging as interchangeable.