Structure-activity relationship of chemically synthesized nonreducing parts of lipid A analogs.
Structure-activity relationship of chemically synthesized nonreducing parts of lipid A analogs.
复制标题
化学合成的脂质 A 类似物非还原部分的构效关系。
DOI：
10.1007/978-1-4757-5140-6_6
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发表时间：
1990
影响因子：
--
通讯作者：
Y. Kumazawa
中科院分区：
文献类型：
--
作者：
J. Homma;M. Matsuura;Y. Kumazawa
近半个世纪以来，内毒素研究人员的主要目标之一是从巨大分子量的复杂化学复合体中发现内毒素的内在化学本质。内毒素-蛋白质复合体是从革兰氏阴性菌细胞壁中首次分离得到的，具有内毒素的全部活性。在几位先驱对内毒素进行了精确的免疫化学研究后，Westphal和Lüderitz声称游离脂A部分负责内毒素活性。这是在20世纪50年代初的S。收集了大量的实验数据，证明游离脂A是导致内毒素的唯一结构(5)。
One of the main aims of endotoxin researchers for almost half a century to date has been to discover the intrinsic chemical nature of endotoxin from complicated chemical complexes of enormous molecular weight. The lipopolysaccharide-protein complex which proved to exhibit all the activities of endotoxin was first isolated from the cell wall of gram-negative bacteria. After precise immunochemical studies on endotoxin by several pioneers, the portion called free lipid A was claimed by Westphal and Lüderitz to be responsible for the endotoxin activities. This was in the early 1950’s. Much experimental data was collected to prove that free lipid A is the sole structure responsible for endotoxicity (5).