Proton-beam irradiated epithelioid cell melanoma of the ciliary body.
Proton-beam irradiated epithelioid cell melanoma of the ciliary body.
复制标题
质子束照射的睫状体上皮样细胞黑色素瘤。
DOI：
10.1016/s0161-6420(81)34883-0
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发表时间：
1981
期刊：
影响因子：
13.7
通讯作者：
Ritch,R
中科院分区：
文献类型：
--
作者：
Zinn,KM;Stein/Pokorny,K;Jakobiec,FA;Friedman,AH;Gragoudas,ES;Ritch,R
睫状体恶性黑色素瘤接受质子束照射。在肿瘤明显没有反应后，眼睛被摘除。一个主要的上皮样细胞肿瘤出现活的光镜下，和低程度的有丝分裂活动持续，尽管治疗。然而，肿瘤细胞在超微结构上显示退行性变化，推测是放射治疗的结果。这些细胞包括大量的细胞骨架丝，脂质空泡，突出的吞噬溶酶体，和核卷曲和碎片。线粒体在本肿瘤中的数量少于通常遇到的上皮样细胞。一种罕见的leptomeric结构被发现，可能是一个组织修改的细胞质丝。肿瘤的毛细血管表现为辐射引起的基底膜增厚和血管周围纤维蛋白沉积的变化。上述特征表明放射治疗造成细胞和代谢损伤，但这些损伤显然不足以使肿瘤灭菌。
A malignant ciliary body melanoma received proton-beam irradiation. After an apparent failure of the tumor to respond, the eye was enucleated. A predominantly epithelioid cell tumor appeared viable by light microscopy, and a low degree of mitotic activity persisted, despite therapy. The tumor cells, however, displayed degenerative changes ultrastructural ly, presumably results of the radiotherapy. These consisted of numerous cytoskeletal filaments, lipid vacuoles, prominent phagolysosomes, and nuclear convolutions and fragmentations. The mitochondria were fewer in number in the present tumor than typically encountered in epithelioid cells. A rare leptomeric structure was discovered, probably an organizational modification of the cytoplasmic filaments. The tumor’s capillaries showed radiation-induced changes in terms of thickened basement membranes and perivascular fibrin deposition. The foregoing features are indicative of cellular and metabolic injury from the radiotherapy, but these were evidently not sufficiently injurious to sterilize the tumor.