Influence of Long-Term Fasting on Blood Redox Status in Humans
Influence of Long-Term Fasting on Blood Redox Status in Humans
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DOI：
10.3390/antiox9060496
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发表时间：
2020-06-01
期刊：
影响因子：
7
通讯作者：
Kouretas, Demetrios
中科院分区：
文献类型：
--
作者：
de Toledo, Francoise Wilhelmi;Grundler, Franziska;Kouretas, Demetrios
禁食越来越多地用于改善健康和一般福祉，以及其细胞保护作用。血液氧化还原状态的变化与各种代谢疾病的发展有关，最近在热量限制和间歇性禁食期间有记录，但长期禁食（LF）没有。我们调查了109名受试者在禁食10天前后的血液氧化还原谱的一些参数。禁食导致体重显著降低，改善健康状况，并对血脂和葡萄糖调节具有有益的调节作用。我们观察到，空腹降低脂质过氧化（TBARS）和增加总抗氧化能力（TAC）在血浆中，伴随着尿酸升高，已知与空腹相关，并没有引起痛风发作。红细胞还原型谷胱甘肽（GSH）、谷胱甘肽还原酶（GR）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶无明显变化。此外，体重、腰围和葡萄糖水平的降低与脂质过氧化反应的减少有关。通过根据GSH水平的变化对受试者进行分组，获得了类似的结果，表明禁食10天可以改善血液氧化还原状态，而不管血液中GSH的状态如何。
Fasting is increasingly practiced to improve health and general well-being, as well as for its cytoprotective effects. Changes in blood redox status, linked to the development of a variety of metabolic diseases, have been recently documented during calorie restriction and intermittent fasting, but not with long-term fasting (LF). We investigated some parameters of the blood redox profile in 109 subjects before and after a 10-day fasting period. Fasting resulted in a significant reduction in body weight, improved well-being and had a beneficial modulating effect on blood lipids and glucose regulation. We observed that fasting decreased lipid peroxidation (TBARS) and increased total antioxidant capacity (TAC) in plasma, concomitant with a uric acid elevation, known to be associated with fasting and did not cause gout attacks. Reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx) and catalase in erythrocytes did not show significant changes. In addition, reduction in body weight, waist circumference, and glucose levels were associated to a reduced lipid peroxidation. Similar results were obtained by grouping subjects on the basis of the changes in their GSH levels, showing that a period of 10 days fasting improves blood redox status regardless of GSH status in the blood.