Increased risk of high-grade anal neoplasia associated with a human papillomavirus type 16 E6 sequence variant
Increased risk of high-grade anal neoplasia associated with a human papillomavirus type 16 E6 sequence variant
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DOI：
10.1086/340125
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发表时间：
2002-05-01
影响因子：
6.4
通讯作者：
Palefsky, JM
中科院分区：
文献类型：
--
作者：
Da Costa, MM;Hogeboom, CJ;Palefsky, JM
16 型人乳头瘤病毒 (HPV) E6 和 E7 基因的表达与肛门生殖器癌前病变和恶性病变的病因有关。为了评估 HPV-16 E6 序列的变异是否与高级别肛门肿瘤的发生率相关，对来自 193 名人类免疫缺陷病毒 (HIV) 阳性和 59 名 HIV 阴性参与者的 628 份 HPV-16 阳性肛门标本进行了 15 个 E6 核苷酸位置变异的分型。尽管大多数参与者感染了原型菌株，但有 15 人（6%）携带 G131 变体，12 人（5%）感染了 Af1a 变体。还发现了两种以前未报道过的新变体。在控制 HIV 状态后，与原型菌株相比，高级别肛门鳞状上皮内病变的风险升高与 G131 变体感染相关（优势比为 3.4；95% 置信区间为 1.1-10）。这些数据进一步证明 HPV 毒株变异是决定肛门生殖器肿瘤自然史的一个因素。
Expression of the E6 and E7 genes of human papillomavirus (HPV) type 16 have been implicated in the etiology of anogenital premalignant and malignant lesions. To evaluate whether variations in the HPV-16 E6 sequence were related to the incidence of high-grade anal neoplasia, 628 HPV-16-positive anal specimens from 193 human immunodeficiency virus (HIV)-positive and 59 HIV-negative participants were typed for variations in 15 E6 nucleotide positions. Although most participants were infected with a prototype strain, 15 (6%) carried the G131 variant, and 12 (5%) were infected with the Af1a variant. Two new variants not previously reported were identified as well. An elevated risk for high-grade anal squamous intraepithelial lesions was associated with infection by G131 variants, compared with the prototype strain (odds ratio, 3.4; 95% confidence interval, 1.1-10), after controlling for HIV status. These data provide further evidence for HPV strain variation as a factor in determining the natural history of anogenital neoplasia.