Presence and persistence of psychotic symptoms in cocaine- versus methamphetamine-dependent participants
Presence and persistence of psychotic symptoms in cocaine- versus methamphetamine-dependent participants
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DOI：
10.1080/10550490701861201
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发表时间：
2008-03-01
影响因子：
3.7
通讯作者：
Newton, Thomas F.
中科院分区：
文献类型：
--
作者：
Mahoney, James J., III;Kalechstein, Ari D.;Newton, Thomas F.
这项研究的主要目的是比较和对比可卡因和甲基苯丙胺依赖者报告的精神症状。参与者包括27名可卡因依赖者和25名甲基苯丙胺依赖者，以及15名可卡因依赖者和18名甲基苯丙胺依赖者。筛查后，如果参与者符合除尼古丁依赖、甲基苯丙胺或可卡因依赖以外的任何Axis I诊断标准，则被排除在外(即参与者必须使用甲基苯丙胺或可卡因，但如果满足两者的依赖标准，则被排除在外)。参与者接受了新开发的精神病症状评估量表(PSAs)，该量表评估精神病症状。有很高比例的依赖可卡因和甲基苯丙胺的男性和女性报告了妄想症和幻听。然而，在禁欲和醉酒条件下，甲基苯丙胺依赖的男性和女性比依赖可卡因的男性和女性更有可能报告精神症状。未来的研究将比较非依赖型娱乐兴奋剂使用者和兴奋剂依赖者报告的精神病症状。
The primary objective of this study was to compare and contrast psychotic symptoms reported by cocaine- and methamphetamine-dependent individuals. Participants included 27 cocaine -dependent and 25 methamphetamine-dependent males, as well as 15 cocoine-dependent and 18 methamphetamine-dependent females. After screening, participants were excluded if they met criteria for any Axis I diagnosis other than nicotine dependence, or methamphetamine or cocaine dependence (ie, participants had to use either methamphetamine or cocaine but were excluded if they met dependence criteria for both). The participants were administered the, newly developed Psychotic Symptom Assessment Scale (PSAS), which assesses psychotic symptoms. A high proportion of both cocaine- and methamphetamine-dependent men and women reported delusions of paranoia and auditory hallucinations. However, during the abstinent and intoxicated conditions, methamphetamine-dependent men and women were more likely than cocaine-dependent men and women to report psychotic symptoms. Future studies will compare psychotic symptoms reported by non-dependent recreational stimulant users to stimulant-dependent individuals.