Early diagnosis of myocardial infarction with MB CK isoforms.
Early diagnosis of myocardial infarction with MB CK isoforms.
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MB CK 亚型对心肌梗塞的早期诊断。
DOI：
10.1016/s0009-8981(97)00250-7
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Roberts,R
中科院分区：
文献类型：
--
作者：
Roberts,R
在美国，每年有500多万胸痛患者到急诊室就诊，但只有10%的患者会有心电确诊为50%的脑梗塞。早期诊断脑梗塞在急诊室分诊可提供更合适的早期治疗，减少不必要的CCU使用，且更具成本效益。在一项前瞻性研究中，对1110名胸痛患者进行了快速自动MB-CK亚型分析(25分钟)。该方法对胸痛发作后6h内诊断心肌梗死的敏感性为96%，特异性为93%。92%的患者在到达急诊室后1小时内确诊。总MB CK、肌钙蛋白T和肌钙蛋白I的敏感度和特异度相似，从疼痛开始需要16小时。因此，MB CK亚型可在脑梗塞发病后早期进行快速诊断，并对急诊室中的分诊患者具有必要的敏感性和特异性。
Over 5 million patients with chest pain present annually to the ER in the US but only 10% will have infarction with <50% identified by ECG. Early diagnosis of infarction in the ER to triage provides more appropriate and early therapy, less unnecessary use of CCU, and is more cost effective. A rapid automated MB CK isoform assay (25 min) was evaluated in a prospective study of 1110 patients presenting to the ER with chest pain. This assay was shown to have a sensitivity of 96% and specificity of 93% to diagnose infarction within 6 h of onset of chest pain. In 92% the diagnosis was confirmed within 1 h of arrival at the ER. Similar sensitivity and specificity for total MB CK, troponin T, and troponin I required 16 h from onset of pain. Thus, MB CK isoforms provide a rapid diagnosis early after onset of infarction and have the requisite sensitivity and specificity for triaging patients in the ER.