Treatment of advanced non-small-cell lung cancer with Chinese herbal medicine by stages combined with chemotherapy
Treatment of advanced non-small-cell lung cancer with Chinese herbal medicine by stages combined with chemotherapy
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DOI：
10.1007/s00432-011-0975-3
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发表时间：
2011-07-01
影响因子：
3.6
通讯作者：
Cai, Xiao Yue
中科院分区：
文献类型：
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作者：
Xu, Zhen Ye;Jin, Chang Juan;Cai, Xiao Yue
为观察中药分期联合化疗治疗III、IV期非小细胞肺癌(NSCLC)的疗效。采用前瞻性、随机、对照、多中心试验设计，将121例非小细胞肺癌患者随机分为治疗组65例和对照组56例。所有患者随机分为单纯化疗组和化疗加中药组(化疗期间给予抗瘤消汤，化疗后给予肺炎宁汤)。主要观察指标为生存时间、Karnofsky评分、主要临床症状和不良反应。5例患者在疾病进展或其他原因后因口服易瑞沙而停止试验，116例患者临床疗效可评价，其中治疗组63例，对照组53例。治疗组总有效率为15.87%，对照组为7.55%(P=0.170)，疾病控制率为85.71%，对照组为71.70%(P=0.063)。中位生存期治疗组为16.17个月，对照组为12.00个月(P=0.165)。治疗组白细胞减少等不良反应明显少于对照组(P=0.039)，中药配合化疗对改善晚期非小细胞肺癌患者的生活质量、延长生存期有良好效果。
To observe the effect of Chinese herbal medicine by stages combined with chemotherapy in treating patients with non-small-cell lung cancer (NSCLC) of stage III or IV.Adopting prospective, randomized, controlled, multi-centered trial design, 121 patients enrolled were assigned to the treatment group (n = 65) and the control group (n = 56). All the patients were randomized to receive chemotherapy alone or chemotherapy and Chinese herbal medicine combined (Kangliuzengxiao decoction during chemotherapy and Feiyanning decoction after chemotherapy). The main outcome measures were survival time, Karnofsky score, main clinical symptoms, and adverse reactions.Five patients discontinued from the trial due to oral administration of Iressa after disease progression or other reasons, and 116 patients were evaluable for clinical efficacy with 63 in the treatment group and 53 in the control group. The overall response rate were 15.87% vs. 7.55% (P = 0.170), and the disease control rate were 85.71% vs. 71.70% in the treatment and control group (P = 0.063), respectively. The median survival time was 16.17 months vs. 12.00 months in the treatment and control group (P = 0.165), respectively. In addition, adverse reactions such as leucopenia in the treatment group were less than those in the control group (P = 0.039).Chinese herbal medicine combined with chemotherapy showed favorable effect in improving quality of life and prolonging survival time on patients with advanced NSCLC.