Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.
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DOI：
10.1146/annurev.biochem.78.082907.145410
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发表时间：
2009
影响因子：
16.6
通讯作者：
Jeffrey M
中科院分区：
文献类型：
--
作者：
Caughey B;Baron GS;Chesebro B;Jeffrey M
随着在哺乳动物和真菌等生物中发现了新的自我繁殖的蛋白质状态，Prion(感染蛋白)的概念已经演变。哺乳动物传染性海绵状脑病(TSE)的病原体长期以来一直被认为是典型的Prion，最近对TSE感染性的无细胞繁殖和生物物理分析现在已经牢固地确立了它的Prion证书。在特定的实验条件下，其他与疾病相关的蛋白质聚集体，如一些淀粉样蛋白，也可以具有类似Pron的特征。然而，大多数淀粉样蛋白似乎缺乏TSE蛋白的天然传递性。后者区别于前者的一个特征是糖磷脂酰肌醇膜锚定在Pron蛋白上，Pron蛋白是TSE疾病中被破坏的分子。这种锚定的存在深刻地影响了TSE的发病机制，这涉及到大脑中主要的膜扭曲，并可能是TSE Prion相对于许多其他自催化蛋白聚集体具有更强的神经毒力的关键原因。
The prion (infectious protein) concept has evolved with the discovery of new self-propagating protein states in organisms as diverse as mammals and fungi. The infectious agent of the mammalian transmissible spongiform encephalopathies (TSE) has long been considered to be the prototypical prion, and recent cell-free propagation and biophysical analyses of TSE infectivity have now firmly established its prion credentials. Other disease-associated protein aggregates, such as some amyloids, can also have prion-like characteristics under certain experimental conditions. However, most amyloids appear to lack the natural transmissibility of TSE prions. One feature that distinguishes the latter from the former is the glycophosphatidylinositol membrane anchor on prion protein, the molecule that is corrupted in TSE diseases. The presence of this anchor profoundly affects TSE pathogenesis, which involves major membrane distortions in the brain, and may be a key reason for the greater neurovirulence of TSE prions relative to many other autocatalytic protein aggregates.
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影响因子：
4.8
作者：
Callahan, NA;Xiong, LW;Caughey, B
通讯作者：
Caughey, B
DOI：
10.1046/j.1365-2990.2000.026002143.x
发表时间：
2000-04-01
影响因子：
5
作者：
Belichenko, PV;Brown, D;Fraser, JR
通讯作者：
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影响因子：
2.9
作者：
Baxa, Ulrich;Wickner, Reed B.;Tycko, Robert
通讯作者：
Tycko, Robert
影响因子：
--
作者：
Caughey, B;Kocisko, DA;Lansbury, PT
通讯作者：
Lansbury, PT
影响因子：
48
作者：
Atarashi, Ryuichiro;Moore, Roger A.;Caughey, Byron
通讯作者：
Caughey, Byron