Possible effects of whole body vibration on bone properties in growing rats
Possible effects of whole body vibration on bone properties in growing rats
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DOI：
10.1016/j.afos.2019.07.001
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发表时间：
2019-08
影响因子：
2
通讯作者：
A. Minematsu;Y. Nishii;H. Imagita;S. Sakata
中科院分区：
文献类型：
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作者：
A. Minematsu;Y. Nishii;H. Imagita;S. Sakata
目的探讨全身振动（WBV）对生长大鼠骨特性的影响，探讨增强骨特性的最佳条件。方法4周龄雄性大鼠36只，分为1个对照组和5个实验组。每个实验组均以 15、30、45、60 和 90Hz（0.5g、15 分钟/天、5 天/周）进行 WBV，持续 8 周。我们测量了右胫骨的骨骼大小、肌肉重量和骨骼机械强度。通过微型计算机断层扫描分析左胫骨的骨小梁质量和骨小梁微结构（TBMS）。还测量了骨形成/吸收标志物的血清水平。结果45Hz和60Hz的WBV倾向于增强小梁骨质量和TBMS参数。然而，所有组间胫骨最大负荷没有差异。 45-Hz WBV组血清骨吸收标志物水平显着高于对照组。结论45-60Hz WBV可能为快速生长期间增加骨量提供有效的方式。需要进一步研究来探索增加峰值骨量和 TBMS 参数的最佳 WBV 条件。 WBV 方式可能是骨质疏松症一级预防的有效策略。
ObjectivesTo examine the effects of whole body vibration (WBV) on bone properties in growing rats, and to explore the optimal conditions for enhancing bone properties.MethodsThirty-six 4-week-old male rats were divided into 1 control and 5 experimental groups. Each experimental group underwent WBV at 15, 30, 45, 60, and 90 Hz (0.5g, 15 min/d, 5 d/wk) for 8 weeks. We measured bone size, muscle weight and bone mechanical strength of the right tibia. Trabecular bone mass and trabecular bone microstructure (TBMS) of the left tibia were analyzed by micro-computed tomography. Serum levels of bone formation/resorption markers were also measured.ResultsWBV at 45 Hz and 60 Hz tended to enhance trabecular bone mass and TBMS parameters. However, there was no difference in maximum load of tibias among all groups. Serum levels of bone resorption marker were significantly higher in the 45-Hz WBV group than in the control group.ConclusionsWBV at 45–60 Hz may offer a potent modality for increasing bone mass during the period of rapid growth. Further studies are needed to explore the optimal WBV conditions for increasing peak bone mass and TBMS parameters. WBV modality may be a potent strategy for primary prevention against osteoporosis.