The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells.
The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells.
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DOI：
10.1007/s00018-009-0132-1
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发表时间：
2010-01
影响因子：
8
通讯作者：
Brabek, Jan
中科院分区：
文献类型：
--
作者：
Pankova, K.;Rosel, D.;Novotny, M.;Brabek, Jan
肿瘤细胞在侵入3D环境时表现出至少两种不同的迁移模式。单个肿瘤细胞的侵袭策略遵循间充质或变形虫模式。某些细胞类型可以使用两种侵袭模式，并在它们之间进行转换。这项工作概述了参与间质和变形虫类型的肿瘤细胞运动的信号通路，并总结了它们之间的转换所涉及的分子机制。重点是Rho家族的小GTP酶，调节细胞迁移过程中发生的依赖细胞因子的过程中的信号转导。Rho蛋白家族、其调节因子和效应因子之间的多重相互作用被认为是特定类型的侵袭性的关键决定因素。间充质和变形虫侵入策略显示与周围基质的不同粘附和蛋白水解相互作用，并且影响这些相互作用的改变也可以导致转变。
Tumor cells exhibit at least two distinct modes of migration when invading the 3D environment. A single tumor cell’s invasive strategy follows either mesenchymal or amoeboid patterns. Certain cell types can use both modes of invasiveness and undergo transitions between them. This work outlines the signaling pathways involved in mesenchymal and amoeboid types of tumor cell motility and summarizes the molecular mechanisms that are involved in transitions between them. The focus is on the signaling of the Rho family of small GTPases that regulate the cytoskeleton-dependent processes taking place during the cell migration. The multiple interactions among the Rho family of proteins, their regulators and effectors are thought to be the key determinants of the particular type of invasiveness. Mesenchymal and amoeboid invasive strategies display different adhesive and proteolytical interactions with the surrounding matrix and the alterations influencing these interactions can also lead to the transitions.
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