Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos
Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos
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分析石棉暴露引起的生物和分子特征以及基因组损伤
DOI：
10.2147/cmar.s205723
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发表时间：
2019
影响因子：
3.3
通讯作者：
Milena Rondón
中科院分区：
文献类型：
--
作者：
D. Ospina;V. Villegas;Giovanni Rodríguez;Milena Rondón
石棉是最重要的职业致癌物之一。目前，全世界约有1.25亿人在工作场所接触石棉。根据全球估计，每年至少有10.7万人因职业接触石棉而死于肺癌、间皮瘤和石棉沉滞症。目前已知这种材料的高致病性与肺部疾病的发生有关，其中肺癌是由于接触这种矿物而导致死亡的主要原因。与石棉有关的肺部疾病是一个常见的临床问题，也是世界范围内的一个主要健康问题。广泛的研究已经确定了许多重要的致病机制；然而，所涉及的精确分子机制，以及导致这些疾病发展的产生的基因组损伤，尚不完全清楚。这种疾病背后的作用模式似乎因纤维类型、肺清除率和基因而异。这证明有必要增加我们对这些对人类健康的影响的认识。本文综述了石棉的特性以及接触石棉对人体细胞和基因组的损害。
Abstract Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure.
影响因子：
56.9
作者：
Engelman, Jeffrey A.;Zejnullahu, Kreshnik;Janne, Pasi A.
通讯作者：
Janne, Pasi A.