REGRESSION OF ATHEROSCLEROTIC LESIONS BY HIGH-DENSITY-LIPOPROTEIN PLASMA FRACTION IN THE CHOLESTEROL-FED RABBIT
REGRESSION OF ATHEROSCLEROTIC LESIONS BY HIGH-DENSITY-LIPOPROTEIN PLASMA FRACTION IN THE CHOLESTEROL-FED RABBIT
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DOI：
10.1172/jci114558
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发表时间：
1990-04-01
影响因子：
15.9
通讯作者：
FUSTER, V
中科院分区：
文献类型：
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作者：
BADIMON, JJ;BADIMON, L;FUSTER, V
在胆固醇喂养的家兔中研究了同源血浆HDL和VHDL组分对已建立的动脉粥样硬化病变的影响。高胆固醇饲料喂养60 d（第1组），建立动脉粥样硬化模型。另一组动物保持相同的饮食90天（组2）。第三组也喂食相同的饮食90天，但在最后30天（第3组）每周接受50 mg HDL-VHDL蛋白（从正常血脂的兔血浆中分离）。研究完成时主动脉粥样硬化累及为34 . ±-.第1组为38.8 ± 4%。第2组为17.8 ± 0.5%。第3组为4%（P < 0.005）。与第1组（仅在60天研究）和第2组相比，第3组的主动脉脂质沉积也显著减少。这是第一个在体内，前瞻性证据的抗动脉粥样硬化作用的HDL-VHDL对预先存在的动脉粥样硬化。我们的研究结果表明，HDL血浆组分能够诱导已建立的主动脉脂肪条纹和脂质沉积的消退。我们的研究结果表明，它可能不仅可以抑制进展，甚至可以减少建立动脉粥样硬化病变的HDL管理。
The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals of 0.5% cholesterol-rich diet for 60 d (group 1). Another group of animals were maintained on the same diet for 90 d (group 2). A third group was also fed the same diet for 90 d but received 50 mg HDL-VHDL protein per wk (isolated from normolipemic rabbit plasma) during the last 30 d (group 3). Aortic atherosclerotic involvement at the completion of the study was 34 .+-. 4% in group 1, 38.8 .+-. 5% in group 2, and 17.8 .+-. 4% in group 3 (P < 0.005). Aortic lipid deposition was also significantly reduced in group 3 compared with group 1 (studied at only 60 d) and group 2. This is the first in vivo, prospective evidence of the antiatherogenic effect of HDL-VHDL against preexisting atherosclerosis. Our results showed that HDL plasma fractions were able to induce regression of established aortic fatty streaks and lipid deposits. Our results suggest that it may be possible not only to inhibit progression but even to reduce established atherosclerotic lesions by HDL administration.