Elevated plasma endothelin concentrations in cyclosporine-treated patients after bone marrow transplantation.
Elevated plasma endothelin concentrations in cyclosporine-treated patients after bone marrow transplantation.
复制标题
骨髓移植后接受环孢素治疗的患者血浆内皮素浓度升高。
DOI：
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发表时间：
1995
影响因子：
4.8
通讯作者：
A. Grünert
中科院分区：
文献类型：
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作者：
Cornelia Haug;T. Duell;A. Lenich;H. Kolb;A. Grünert
环孢霉素的给药通常与肾功能不全和高血压的发展有关。由于最近的动物实验数据提供的证据表明，内皮素，一种有效的血管收缩肽，可能在介导环孢素相关的肾脏和心血管副作用中发挥作用，本研究旨在研究环孢素治疗的患者血浆内皮素浓度是否升高。血浆内皮素浓度，测定放射免疫分析法后，Sep Pak C18提取，显着升高环孢素治疗的患者骨髓移植后（8.3 +/- 1.4 ng/l，n = 28）与骨髓移植后未接受环孢素治疗的患者相比（3.9 +/- 0.2* ng/l，n - 11），血液系统疾病患者（3.9 +/- 0.3** ng/l，n = 11）未接受骨髓移植和正常对照受试者（3.1 +/- 0.2* ng/l，n = 33）（*P < 0.05，**P < 0.01，*P < 0.001）。血浆内皮素水平与环孢素浓度呈显著正相关（r = 0.57，P < 0.01）。目前的数据表明，环孢素治疗的患者血浆内皮素浓度升高，表明环孢素相关的肾脏和心血管副作用可能部分介导的环孢素诱导的刺激内皮素释放。
Administration of cyclosporine is often associated with the development of renal dysfunction and hypertension. Since recent data from animal experiments provide evidence that endothelin, a potent vasoconstrictive peptide, might play a role in mediating cyclosporine-related renal and cardiovascular side-effects, the present study was designed to investigate whether plasma endothelin concentrations are elevated in cyclosporine-treated patients. Plasma endothelin concentrations, determined by radioimmunoassay after Sep Pak C18 extraction, were significantly elevated in cyclosporine-treated patients after bone marrow transplantation (8.3 +/- 1.4 ng/l, n = 28) compared to patients not treated with cyclosporine after bone marrow transplantation (3.9 +/- 0.2* ng/l, n - 11), patients with haematological disorders (3.9 +/- 0.3** ng/l, n = 11) not treated with bone marrow transplantation and to normal control subjects (3.1 +/- 0.2*** ng/l, n = 33) (*P < 0.05, **P < 0.01, ***P < 0.001). Furthermore, plasma endothelin levels exhibited a significant correlation with cyclosporine concentrations (r = 0.57, P < 0.01). The present data, demonstrating elevated plasma endothelin concentrations in cyclosporine-treated patients, suggest that the cyclosporine-associated renal and cardiovascular side-effects might in part be mediated by cyclosporine-induced stimulation of endothelin release.