Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells.
Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells.
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氮卓斯汀抑制免疫诱导的豚鼠肥大细胞释放组胺。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
W. Schmutzler
中科院分区：
文献类型：
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作者：
B. Fischer;W. Schmutzler
4-（p-Chlorobenzyl）-2-（hexahydro-1-methyl-1H-azepin-4-yl）-1-（2 H）-phthalazinone（azelastine，A 5610）不影响自发性组胺释放，但能有效抑制主动致敏豚鼠肠系膜肥大细胞的过敏性组胺释放。在10（-6）mol/l浓度下，抑制作用几乎与肾上腺素（10（-8）mol/l）相同。
4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone (azelastine, A 5610) did not affect the spontaneous histamine release but inhibited effectively the allergic histamine release from isolated mesenteric mast cells of actively sensitized guinea pigs. At 10(-6) mol/l concentration the inhibition was almost equal to that caused by adrenaline (10(-8) mol/l).