NONINVASIVE DIFFERENTIATION OF TUMORS WITH USE OF LOCALIZED H-1 MR SPECTROSCOPY INVIVO - INITIAL EXPERIENCE IN PATIENTS WITH CEREBRAL-TUMORS
NONINVASIVE DIFFERENTIATION OF TUMORS WITH USE OF LOCALIZED H-1 MR SPECTROSCOPY INVIVO - INITIAL EXPERIENCE IN PATIENTS WITH CEREBRAL-TUMORS
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DOI：
10.1148/radiology.172.2.2748837
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发表时间：
1989-08-01
期刊：
影响因子：
19.7
通讯作者：
HAMBURGER, C
中科院分区：
文献类型：
--
作者：
BRUHN, H;FRAHM, J;HAMBURGER, C
最近开发的一种方法，图像选择定位氢-1磁共振（MR）波谱进行了评估，在9个原发性和继发性脑肿瘤的鉴别诊断，其中包括4个胶质瘤，脑膜瘤，神经鞘瘤，蛛网膜囊肿，和乳腺癌转移瘤。这些肿瘤的H-1 MR谱是在体内用常规的1.5 T全身MR成像系统获得的。所有肿瘤的光谱与正常脑组织的光谱明显不同。从不同的肿瘤获得的光谱表现出可重复的差异，而组织学上相似的肿瘤产生的特征光谱只有微小的差异。观察到的光谱变化反映了组织内游离（移动的）代谢物的H-1 MR敏感池的浓度和弛豫时间的变化。在大多数情况下，N-乙酰基-天冬氨酸和肌酸/磷酸肌酸的浓度降低到可检测性以下，而含胆碱化合物通常增加。肿瘤之间的光谱差异主要是由于脂质、乳酸和碳水化合物的浓度不同。局部H-1磁共振波谱可能成为一个重要的临床工具，肿瘤的分化以及治疗控制。
A recently developed method for image-selected localized by hydrogen-1 magnetic resonance (MR) spectroscopy was assessed in the differential diagnosis of nine primary and secondary cerebral tumors, including four gliomas, two meningiomas, one neurilemoma, one arachnoid cyst, and one metastasis of breast cancer. Well-resolved H-1 MR spectra of these tumors were obtained in vivo with a conventional 1.5-T whole-body MR imaging system. All tumor spectra were remarkably different from spectra from normal brain tissue. Spectra obtained from different tumors exhibited reproducible differences, while histologically similar tumors yielded characteristic spectra with only minor differences. The observed spectral alterations of reflect variations in concentrations and relaxation times of the H-1 MR sensitive pool of free (mobile) metabolites within the tissues. In most cases, the concentrations of N-acetyl-aspartate and creatine/phosphocreatine are reduced below detectability, whereas choline-containing compounds are generally enhanced. The spectral differences between the tumors are mainly due to the differing concentrations of lipids, lactic acid, and carbohydrates. Localized H-1 MR spectroscopy may become an important clinical tool for the differentiation of tumors as well as for therapeutic control.