Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.
Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.
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未能在来自恐慌症患者和代表欧洲和美国人群的对照个体的淋巴母细胞中检测到 DUP25。
DOI：
10.1038/sj.ejhg.5201181
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Goldman,David
中科院分区：
文献类型：
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作者：
Zhu,Guanshan;Bartsch,Oliver;Skrypnyk,Cristina;Rotondo,Alessandro;Akhtar,LonginaA;Harris,Claudia;Virkkunen,Matti;Cassano,Giovanni;Goldman,David
对惊恐症和恐惧症与关节松弛同时发生的调查发现，西班牙人群中存在涉及人类染色体 15q24-26（称为“DUP25”）的间质重复。在 97% 的患者和 7% 的对照个体中观察到 DUP25。在本研究中，我们使用两种不同的方法来检测DUP25：高通量分子基因剂量分析和荧光原位杂交（FISH）。我们评估了 56 个淋巴母细胞系，这些细胞系来自 26 名无关的惊恐障碍患者，这些患者来自几个欧洲和美国人群以及 30 名正常对照。我们找不到任何显示与 DUP25 一致结果的细胞系。这些数据不支持 DUP25 与恐慌症有任何关联。
Investigation of the co-occurrence of panic and phobic disorders with joint laxity led to the identification of interstitial duplications involving human chromosome 15q24–26 (named ‘DUP25’) in a Spanish population. DUP25 was observed in 97% of patients and in 7% of control individuals. In the present study, we used two different methods to detect DUP25: high-throughput molecular gene dosage analysis and fluorescence in situ hybridization (FISH). We evaluated 56 lymphoblastoid cell lines derived from 26 unrelated patients with panic disorder obtained from several European and American populations and 30 normal controls. We could not find any cell line showing a result consistent with DUP25. These data do not support any association of DUP25 with panic disorder.