Prognostic Impact of Baseline High-Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Based on Body Mass Index
Prognostic Impact of Baseline High-Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Based on Body Mass Index
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DOI：
10.4070/kcj.2012.42.3.164
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发表时间：
2012-03-01
影响因子：
2.9
通讯作者：
Kim, Young Jo
中科院分区：
文献类型：
--
作者：
Ahmed, Khurshid;Jeong, Myung Ho;Kim, Young Jo
背景和目的：血清高敏 C 反应蛋白 (hs-CRP) 是炎症标志物，可能导致动脉粥样硬化的发展，对死亡率产生不利影响。本研究的目的是根据体重指数（BMI）状况评估接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死（AMI）患者基线hs-CRP水平与12个月临床结果之间的关系。 对象和方法：使用2005年11月至2008年9月韩国急性心肌梗死登记处的数据，对总共8174名连续AMI患者进行了研究。 Cox 比例风险模型显示，较高的 hs-CRP 基线水平与 12 个月全因死亡率相关 (p=0.045)。为了进一步了解这种关联，根据体重指数将患者分为 3 组：1）超重/肥胖，2）正常体重，3）体重不足。然后根据 hs-CRP 将每组分为四分位数。 结果：在超重/肥胖患者中，Cox 模型显示，在调整年龄和性别后，hs-CRP 与 12 个月死亡率显着相关 (p= 4.08 mg/dL)，在超重/肥胖 AMI 患者中，显示与 12 个月全因死亡率显着相关，与其他预后标志物无关。
Background and Objectives: Serum high sensitivity C-reactive protein (hs-CRP) is a marker of inflammation and may lead to the development of atherosclerosis, adversely affecting mortality. The aim of this study was to evaluate the relationship between baseline hs-CRP level and 12-month clinical outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) according to their body mass index (BMI) status.Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry from November 2005 to September 2008, a total of 8174 consecutive AMI patients were studied. Cox proportional hazard model revealed that higher baseline levels of hs-CRP was associated with 12-month all-cause mortality (p=0.045). To further understand this association, patients were divided into 3 groups based on their body mass index: 1) overweight/obese, 2) normal weight, and 3) underweight patients. Then each group was stratified into quartiles based on their hs-CRP.Results: In overweight/obese patients, Cox model showed significant association of hs-CRP with 12-month mortality when adjusted for age and gender (p= 4.08 mg/dL) in overweight/obese AMI patients showed significant association with 12-month all-cause mortality independent of other prognostic markers.