Parent-child factors and their effect on communicating BRCA1/2 test results to children
Parent-child factors and their effect on communicating BRCA1/2 test results to children
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DOI：
10.1016/s0738-3991(01)00192-6
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发表时间：
2002-06-01
影响因子：
3.5
通讯作者：
Lerman, C
中科院分区：
文献类型：
--
作者：
Tercyak, KP;Peshkin, BN;Lerman, C
本研究的目的是评估父母-子女因素对沟通母亲乳腺癌/卵巢癌风险基因检测结果的可能性和影响。受试者是参加遗传性乳腺癌研究项目的42名母亲，他们报告了他们与68名目标儿童的相互作用，预测变量在母亲参加全面的遗传咨询/教育课程并提供血液样本进行BRCA 1/2突变分析后，在基线时评估（人口统计学，临床和心理学）。在母亲了解其突变状态后一个月，评估母亲将检测结果传达给儿童的情况。对儿童的披露率为53%。年龄较大的儿童比年龄较小的儿童更有可能被告知母亲的测试结果。母亲向孩子透露基因检测结果也更有可能发生在更开放的亲子沟通风格的存在，虽然披露行为似乎没有影响沟通风格。这些研究结果表明，除了发育阶段，家庭行为互动和沟通方式强烈预测母亲是否选择与孩子分享癌症遗传风险信息。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The purpose of the present study was to evaluate the likelihood and the effect of parent-child factors on communicating about maternal genetic test results for breast/ovarian cancer risk, Subjects were 42 mothers enrolled in a hereditary breast cancer research program who reported on their interactions with 68 target children, Predictor variables (demographic, clinical, and psychological) were assessed at baseline after mothers participated in a comprehensive genetic counseling/education session and provided a blood sample for BRCA1/2 mutation analysis. Maternal communication of test results to children was assessed I month after mothers learned their mutation status. The rate of disclosure to pediatric-age children was 53%. Older children were more likely to be informed of their mothers' test results than were younger children. Maternal disclosure of genetic test results to children was also more likely to occur in the presence of more open parent-child communication styles, though the act of disclosing did not appear to impact communication style. These findings suggest that in addition to developmental phase, family behavioral interactions and communication styles are strongly predictive of whether or not mothers choose to share cancer genetic risk information with their children. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.