Development of chiral stationary phases for high-performance liquid chromatographic separation
Development of chiral stationary phases for high-performance liquid chromatographic separation
复制标题
高效液相色谱分离手性固定相的开发
DOI：
10.1016/j.trac.2012.07.006
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发表时间：
2012-10-01
影响因子：
13.1
通讯作者：
Liu, Weiping
中科院分区：
文献类型：
--
作者：
Tang, Mengling;Zhang, Jing;Liu, Weiping
基于手性固定相（CSP）的对映体分离色谱技术广泛应用于生物化学品（如药物、食品、香料和污染物）的拆分和制备。在本综述中，我们重点关注高效液相色谱（HPLC）中CSP的发展，包括经典CSP的识别机制、应用和局限性、新发现的CSP类型，以及基于计算化学合理设计未来CSP的方法。 Crown 版权所有 (c) 2012 由 Elsevier Ltd 出版。保留所有权利。
Chromatography technology based on chiral stationary phases (CSPs) for enantioseparation is widely used for resolution and preparation of biochemicals (e.g., drugs, foods, fragrances and pollutants).In this review, we focus on the development of CSPs for high-performance liquid chromatography (HPLC), including the recognition mechanism, applications and limitations of classical CSPs, newly discovered types of CSP, and also the methods for the rational design of future CSPs on the basis of computational chemistry. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.