DANTROLENE DOSE-RESPONSE IN MALIGNANT HYPERTHERMIA-SUSCEPTIBLE (MHS) SWINE - METHOD TO OBTAIN PROPHYLAXIS AND THERAPEUSIS
DANTROLENE DOSE-RESPONSE IN MALIGNANT HYPERTHERMIA-SUSCEPTIBLE (MHS) SWINE - METHOD TO OBTAIN PROPHYLAXIS AND THERAPEUSIS
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DOI：
10.1097/00000542-198004000-00003
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发表时间：
1980-01-01
期刊：
影响因子：
8.8
通讯作者：
NELSON, TE
中科院分区：
文献类型：
--
作者：
FLEWELLEN, EH;NELSON, TE
论文检验了产生 95% 最大肌肉松弛 (ED95) 的丹曲林 [DL] 剂量将有效预防或治疗恶性高热 (MH)。在一组对恶性高热 (MHS) 敏感的 4 头猪中，静脉注射的剂量反应DL 通过脚趾抽搐张力的定量来确定。得出 ED95 松弛剂剂量 (3.5 mg/kg)。在第二组 4 头 MHS 猪中，在 MH 攻击之前施用 ED95 DL 剂量，使用 2 mg/kg 琥珀胆碱和 1.5% 氟烷。预防每只动物的 MH，同时测量动脉压、动脉血气、pH 值和乳酸值、直肠温度和心率。当这 4 只动物再次受到挑战时，MH 迅速发展。当用 ED95 剂量治疗时，每只动物都存活下来。每头猪都在没有 DL 预防或治疗的情况下受到攻击，并且全部死于 MH。先前的研究表明，DL 可有效预防或治疗猪 MH，但使用的剂量各不相同，没有任何道理。本研究表明，在 MHS 猪中，ED95 肌松剂剂量的 DL（3.5 毫克/千克）可成功预防和治疗 MH。
The thesis that a dose of dantrolene [DL] producing 95% of maximal muscle relaxation (ED95) would effectively prevent or treat malignant hyperthermia (MH) was examined. In 1 group of 4 pigs sensitive to malignant hyperthermia (MHS) a dose response to i.v. DL was determined by quantitation of toe twitch tension. The ED95 relaxant dose (3.5 mg/kg) was derived. In a 2nd group of 4 MHS pigs, the ED95 DL dose was administered prior to MH challenge with succinylcholine, 2 mg/kg, and halothane, 1.5%. MH was prevented in each animal, while measurements of arterial pressure, arterial blood-gas, pH and lactate values, rectal temperature and heart rate were done. MH rapidly developed in the same 4 animals when they were again challenged. When treated with the ED95 dose, each animal survived. Each pig was challenged without DL prophylaxis or therapeusis, and all succumbed from MH. Previous studies have shown the efficacious use of DL in prevention or treatment of porcine MH, but doses used have varied, without rationale. The present study shows that in MHS pigs the ED95 muscle relaxant dose of DL (3.5 mg/kg) successfully prevents and treats MH.