Sorting within the regulated secretory pathway occurs in the trans-Golgi network.
Sorting within the regulated secretory pathway occurs in the trans-Golgi network.
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DOI：
10.1083/jcb.110.1.1
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发表时间：
1990-01
期刊：
影响因子：
--
通讯作者：
Scheller RH
中科院分区：
文献类型：
--
作者：
Sossin WS;Fisher JM;Scheller RH
生物活性肽裂解的产卵激素前体在袋细胞神经元的Aaplasia被分为不同的致密核心囊泡类（DCV）。囊细胞激素原加工可分为两个阶段，最初的分裂发生在后期高尔基体隔室，这是不阻断莫能菌素，和后来的分裂发生在DCV和莫能菌素阻断。激素原中间体在反式高尔基体网络中排序。大的体细胞特异性DCV翻转，而小的DCV被运输到过程中进行调节释放。因此，蛋白质运输差异地调节源自共同激素原的多种生物活性肽的水平和定位。
Bioactive peptides cleaved from the egg-laying hormone precursor in the bag cell neurons of Aplysia are sorted into distinct dense core vesicle classes (DCVs). Bag cell prohormone processing can be divided into two stages, an initial cleavage occurring in a late Golgi compartment, which is not blocked by monensin, and later cleavages that occur within DCVs and are blocked by monensin. Prohormone intermediates are sorted in the trans-Golgi network. The large soma-specific DCVs turn over, while the small DCVs are transported to processes for regulated release. Thus, protein trafficking differentially regulates the levels and localization of multiple biologically active peptides derived from a common prohormone.