Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia
Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia
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DOI：
10.1016/j.ajoms.2015.01.001
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发表时间：
2015-07-01
影响因子：
0.4
通讯作者：
Komori, Takahide
中科院分区：
文献类型：
--
作者：
Matsumoto, Kousuke;Suzuki, Hiroaki;Komori, Takahide
目的：以往的研究描述了口腔白斑的临床统计和治疗结果。然而，由于白斑的临床诊断往往没有任何组织病理学检查，目前对治疗方法和术前病理诊断的意见并不一致，而且没有针对口腔白斑的标准的部位特异性治疗指南。本研究旨在探讨二氧化碳激光治疗舌白斑的临床疗效。方法：对2001年至2010年间在我科接受CO2激光治疗的35例舌白斑患者的38处病变进行临床观察。我们调查了这些病例的性别差异、年龄分布、左右差异、临床分型、组织病理学诊断(有无上皮异型增生)、治疗方法(切除或蒸发)、复发率、残留率和恶变。结果：在符合纳入条件的38个病变中，35个被切除，3个被蒸发。CO2激光治疗后舌白斑复发率为10.5%，残留率为7.9%。本研究病例的复发率低于本院(2004年)及其他医院报道的复发率。结论：本院采用CO2激光切除加Lugol染色的方法治疗舌白斑是有效的。(C)2015年亚洲AOMS、ASOMP、JSOP、JSOMS、JSOM和JAMI。爱思唯尔有限公司出版。保留所有权利。
Objective: Previous studies have described the clinical statistics and treatment outcomes of leukoplakia of the oral cavity. However, because leukoplakia is often clinically diagnosed without any histopathological examination, current opinion regarding treatment methods and preoperative pathological diagnosis is inconsistent and no standard site-specific treatment guidelines exist for oral leukoplakia. The purpose of this study is to clinically evaluate carbon dioxide (CO2) laser treatment for leukoplakia of the tongue.Methods: We examined 38 lesions in 35 patients of lingual leukoplakia who underwent CO2 laser treatment with using Lugol staining at our department over a 10-year period, i.e., from 2001 to 2010. We investigated gender-related differences, age distribution, left and right differences, clinical classification, histopathological diagnosis (presence or absence of epithelial dysplasia), treatment technique (excision or evaporation), recurrence rate, residual rate, and malignant transformation among these cases.Results: Of the 38 lesions that fulfilled the inclusion requirements, 35 were excised and 3 were evaporated. After CO2 laser treatment, the recurrence and residual rates for lingual leukoplakia were 10.5% and 7.9%, respectively. The recurrence rate of cases examined in this study was lower than that reported by our hospital previously (2004) and many other hospitals. None of the lesions exhibited malignant transformation.Conclusions: Our results suggest that the CO2 laser excision method with using Lugol staining, as performed at our hospital, is useful for the treatment of lingual leukoplakia. (C) 2015 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.