Lipoatrophy among HIV-infected patients is associated with higher levels of depression than lipohypertrophy.
Lipoatrophy among HIV-infected patients is associated with higher levels of depression than lipohypertrophy.
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DOI：
10.1111/j.1468-1293.2008.00631.x
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发表时间：
2008-10
期刊：
影响因子：
3
通讯作者：
Kitahata MM
中科院分区：
文献类型：
--
作者：
Crane HM;Grunfeld C;Harrington RD;Uldall KK;Ciechanowski PS;Kitahata MM
We sought to determine the association between body morphology abnormalities and depression examining lipoatrophy and lipohypertrophy separately. Observational cross-sectional study of 250 patients from the University of Washington HIV Cohort. Patients completed an assessment including depression and body morphology. We used linear regression analysis to examine the association between lipoatrophy, lipohypertrophy, and depression. ANOVA was used to examine the relationship between mean depression scores and lipoatrophy and lipohypertrophy in 10 body regions. Of 250 patients, 76 had lipoatrophy, and 128 had lipohypertrophy. Mean depression scores were highest among patients with moderate-to-severe lipoatrophy (16.4), intermediate among those with moderate-to-severe lipohypertrophy (11.7), mild lipohypertrophy (9.9), and mild lipoatrophy (8.5), and lowest among those without body morphology abnormalities (7.7) (p=0.002). After adjustment, mean depression scores for subjects reporting moderate-to-severe lipoatrophy were 9.2 points higher (p<0.001), scores for subjects with moderate-to-severe lipohypertrophy were 4.8 points higher (p=0.02), and scores for subjects with mild lipohypertrophy were 2.8 points higher (p=0.03) than patients without body morphology abnormalities. Facial lipoatrophy was the body region associated with the most severe depression scores (15.5 versus 8.9 for controls, p=0.03). In addition to long-term cardiovascular implications, body morphology has a more immediate effect on depression severity.
