Methionine Redox Homeostasis in Protein Quality Control.
Methionine Redox Homeostasis in Protein Quality Control.
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DOI：
10.3389/fmolb.2021.665492
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发表时间：
2021
影响因子：
5
通讯作者：
Ezraty B
中科院分区：
文献类型：
--
作者：
Aussel L;Ezraty B
细菌生活在不同的环境中，并受到各种各样的波动条件。在进化过程中，它们获得了专门用于维持蛋白质结构和功能的复杂系统，特别是在氧化应激期间。在这种条件下，蛋氨酸残基转化为蛋氨酸亚砜（Met-O），可以改变蛋白质功能。本文综述了蛋氨酸亚砜还原酶（Msr）在蛋白质质量控制中的作用。我们讨论了我们目前的理解的重要性，Msr系统在抢救蛋白质功能氧化应激和他们的工作能力，在协调与分子伴侣网络。此外，我们强调，细菌分子伴侣，如GroEL或SurA，也是氧化应激的目标，并在Msr的监督下。因此，在氧化应激过程中，蛋氨酸氧化还原稳态在蛋白质质量控制中的整合提供了这种细菌适应机制的完整画面。
Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress. Under such conditions, methionine residues are converted into methionine sulfoxide (Met-O) which can alter protein function. In this review, we focus on the role in protein quality control of methionine sulfoxide reductases (Msr) which repair oxidatively protein-bound Met-O. We discuss our current understanding of the importance of Msr systems in rescuing protein function under oxidative stress and their ability to work in coordination with chaperone networks. Moreover, we highlight that bacterial chaperones, like GroEL or SurA, are also targeted by oxidative stress and under the surveillance of Msr. Therefore, integration of methionine redox homeostasis in protein quality control during oxidative stress gives a complete picture of this bacterial adaptive mechanism.