Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs.
Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs.
复制标题
通过选择性灌注狗的空肠释放神经降压素。
DOI：
10.1016/0016-5085(89)90518-0
复制
发表时间：
1989
期刊：
影响因子：
29.4
通讯作者：
Thompson,JC
中科院分区：
文献类型：
--
作者：
Fujimura,M;Khalil,T;Sakamoto,T;GreeleyJr,GH;Salter,MG;TownsendJr,CM;Thompson,JC
血浆神经降压素浓度在口服或十二指肠内注入脂肪后迅速升高，明显是在脂肪到达神经降压素高度集中的回肠之前。本研究的目的是研究清醒犬神经降压素的释放部位，并确定是否通过脂肪直接腔刺激释放神经降压素。用分离的空肠或回肠段和门静脉导管制备犬模型。用油酸钠选择性灌流肠段，观察神经降压素在门静脉血中的释放情况。这项研究的结果表明，选择性地灌流空肠，而不是回肠，油酸钠可以引起神经降压素的显著释放。我们推测，回肠神经降压素的释放不是由腔内直接刺激引起的，而是由局部神经或体液中介调节的。
Plasma neurotensin concentrations are rapidly elevated after oral ingestion or intraduodenal infusion of fat, apparently before fat reaches the ileum where neurotensin is highly concentrated. The purpose of this study was to investigate the site of neurotensin release and to determine whether neurotensin is released by direct luminal stimulation by fat in conscious dogs. Dogs were prepared with isolated jejunal or ileal segments and portal vein catheters. Release of neurotensin into the portal venous blood was examined by selective perfusion of each intestinal segment with sodium oleate. The results of this study show that selective perfusion of the jejunum, but not the ileum, with sodium oleate, caused a significant release of neurotensin. We speculate that release of ileal neurotensin is not due to direct luminal stimulation, but is mediated by local neural or humoral intermediates.