Nonhuman primate models for human disease.
Nonhuman primate models for human disease.
复制标题
人类疾病的非人类灵长类动物模型。
DOI：
10.1016/b978-0-12-039228-5.50014-0
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Harold M. McClure
中科院分区：
文献类型：
--
作者：
Harold M. McClure
非人类灵长类动物作为多种人类疾病模型的价值已得到充分证明。在过去25年左右的时间里，这些物种被广泛用作各种细菌、病毒和寄生虫病的模型，无论是自然发生的还是实验诱导的感染。它们往往是唯一易受人类疾病病原体实验性感染的非人类物种。非人类灵长类动物的自发性疾病通常与人类疾病相当，并且随着非人类灵长类动物在实验室和国内繁殖群体中的持续长期维持，有理由假设将发现其他疾病模型。这种模型可以包括退行性疾病、与衰老过程相关的疾病和/或病变以及遗传性疾病。在这篇文章中，我们回顾了四种自发疾病和一种诱导疾病，它们在人类中具有基本相同的对应物。其中三种是细菌性疾病，目前在人类中引起严重的，有时是致命的感染；一种是退化性疾病，通常对人类来说是进行性和致命的，另一种可能是遗传疾病，目前没有动物模型。这些非人类灵长类动物疾病与人类疾病的临床和病理相似性使这些非人类灵长类动物疾病成为进一步研究这些严重且往往致命的人类疾病的病因、发病机制和治疗的潜在有价值的模型。
The value of nonhuman primates as models for a variety of human diseases is well documented. These species have been used extensively during the past 25 years or so as models for a variety of bacterial, viral, and parasitic diseases, either as naturally occurring or experimentally induced infections. They are often the only nonhuman species susceptible to experimental infection with agents of human disease. Spontaneous diseases of nonhuman primates are often comparable to human diseases, and with the continued long-term maintenance of nonhuman primates in the laboratory as well as in domestic breeding colonies, it is reasonable to assume that additional disease models will be discovered. Such models may include degenerative diseases, diseases and/or lesions associated with the aging process, and genetic diseases. In this article we have reviewed four spontaneous diseases and one induced disease that have essentially identical counterparts in humans. Three of these are bacterial diseases that currently cause severe and sometimes fatal infections in humans; one is a degenerative disease that is usually progressive and fatal in humans, and one is possibly a genetic disease for which there is currently no animal model. The clinical and pathologic similarities between these nonhuman primate diseases and their human counterpart make these nonhuman primate diseases potentially valuable models for further studies on the etiology, pathogenesis, and treatment of these serious and often fatal human diseases.