Nectin-1 expression in cancer-associated fibroblasts is a predictor of poor prognosis for pancreatic ductal adenocarcinoma
Nectin-1 expression in cancer-associated fibroblasts is a predictor of poor prognosis for pancreatic ductal adenocarcinoma
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DOI：
10.1007/s00595-017-1618-3
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发表时间：
2018-05-01
期刊：
影响因子：
2.5
通讯作者：
Nakagohri, Toshio
中科院分区：
文献类型：
--
作者：
Yamada, Misuzu;Hirabayashi, Kenichi;Nakagohri, Toshio
Nectin-1是一种调节粘附连接和紧密连接形成的细胞粘附分子。我们测量了胰腺导管腺癌（PDAC）患者癌症相关成纤维细胞（CAF）中Nectin-1的表达。使用从258例患者切除的PDAC组织构建的组织微阵列块，通过免疫组织化学方法测量Nectin-1的表达。我们筛选了nectin-1表达与临床病理参数之间的相关性。根据CAFs的染色百分比，30%为阴性，64例CAFs中证实Nectin-1表达与淋巴结转移有关（p = 0.016），国际癌症控制联盟晚期（p = 0.016）、神经周围浸润（p = 0.022）、胰头肿瘤（p = 0.023）和较短的总生存期（p = 0.003）。多因素分析显示，Nectin-1在CAFs中的表达是独立的预后因素（p = 0.038），Nectin-1在PDAC患者CAFs中的弥漫性表达与浸润、转移和生存期缩短相关。
Nectin-1 is a cell adhesion molecule that regulates the formation of adherens junctions and tight junctions. We measured the expression of nectin-1 in cancer-associated fibroblasts (CAFs) in patients with pancreatic ductal adenocarcinoma (PDAC).Nectin-1 expression was measured via immunohistochemistry using tissue microarray blocks constructed from resected PDAC tissue from 258 patients. We screened for associations between nectin-1 expression and clinicopathological parameters. According to the percentage of CAFs stained, expression was classified as negative at 30%.Nectin-1 expression was confirmed in CAFs from 64 patients (24.8%), and was associated with lymph node metastasis (p = 0.016), advanced Union for International Cancer Control stage (p = 0.016), perineural invasion (p = 0.022), pancreatic head tumors (p = 0.023), and shorter overall survival (p = 0.003). Multivariate analysis revealed that nectin-1 expression in CAFs was an independent prognostic factor (p = 0.038).Diffuse nectin-1 expression in the CAFs of PDAC patients is associated with invasion, metastasis, and shorter survival.