Tailoring the biodegradability of porous silicon nanoparticles
Tailoring the biodegradability of porous silicon nanoparticles
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DOI：
10.1002/jbm.a.34294
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发表时间：
2012-12-01
影响因子：
4.9
通讯作者：
Jalali, Bahram
中科院分区：
文献类型：
--
作者：
Hon, Nick K.;Shaposhnik, Zory;Jalali, Bahram
多孔硅纳米粒子是纳米医学中具有吸引力的靶向给药载体。对于体内应用，PSiNP的生物降解性质提供了它们从体内安全清除的途径。80 - 120 nm的颗粒尺寸是特别令人感兴趣的，因为它们对于细胞应用（例如用于癌症治疗的药物递送）是重要的，因为这些纳米颗粒可以利用增强的渗透性和保留效应来优先将药物递送到具有渗漏脉管系统的肿瘤，但足够大以避免肾清除。然而，这种颗粒的生物降解速率通常太快，这限制了颗粒的半衰期并潜在地降低了它们的体内递送效率。在这项工作中，我们专注于纳米级颗粒的降解，并研究热氧化和二氧化硅涂层对PSiNPs在磷酸盐缓冲盐水溶液（一种接近模拟的基本生物流体）中的稳定性的影响。使用热氧化，PSiNP的半衰期可以从10分钟到3小时不等。使用二氧化硅涂层，半衰期可进一步延长至8 h。使用这两种技术生产的颗粒可以使用为药物递送应用开发的标准二氧化硅表面化学进行官能化。(c)2012 Wiley Periodicals，Inc. J Biomed Mater Res Part A：100A：34163421，2012.
Porous silicon nanoparticles (PSiNPs) are attractive carriers for targeted drug delivery in nanomedicine. For in vivo applications, the biodegradation property of PSiNPs provides a pathway for their safe clearance from the body. Particles sizes of 80120 nm are of particular interest as they are important for cellular applications, such as drug delivery for cancer therapy, because these nanoparticles can take advantage of the enhanced permeability and retention effect to deliver drug preferentially to tumors with leaky vasculature, yet large enough to avoid renal clearance. However, the biodegradability rate of such particles is often too fast, which limits particle half-life and potentially reduces their in vivo delivery efficiency. In this work, we focus on the degradation of nanoscale particles and study the effect of both thermal oxidation and silica coating on the stability of PSiNPs in phosphate buffered saline solution (a close mimic of a basic biological fluid). Using thermal oxidation, the half-life of PSiNPs can be varied from 10 min up to 3 h. Using silica coating, the half-life can be extended further to 8 h. The particles produced using both these techniques can be functionalized using standard silica surface chemistries developed for applications in drug delivery. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:34163421, 2012.