ALCOHOL PREFERENCE IN LABORATORY RAT INDUCED BY HYPOTHALAMIC STIMULATION
ALCOHOL PREFERENCE IN LABORATORY RAT INDUCED BY HYPOTHALAMIC STIMULATION
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DOI：
10.1007/bf00403808
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发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
WISE, RA
中科院分区：
文献类型：
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作者：
AMIT, Z;STERN, MH;WISE, RA
通过电刺激下丘脑外侧区，诱导Wistar大鼠饮用厌恶性酒精溶液。与对照动物相比，它们在饲养笼中的酒精摄入量增加了。酒精导向行为的变化在脑刺激治疗终止后仍在继续。实验动物对酒精的偏好超过了对水的偏好，对酒精剂量增加的耐受性和酒精依赖性，如戒断应激所示。他们喝酒，即使是被奎宁污染的。这些数据表明酒精溶液成瘾的发展。
Wistar rats were induced to drink aversive alcohol solutions by electrical stimulation in the lateral-hypothalamus. They increased their home-cage intake of alcohol over that of control animals. Changes in alcohol-directed behavior continued after termination of the brain-stimulation treatment. Experimental animals developed a preference for alcohol over water, tolerance for increasing doses of alcohol and alcohol dependence, as shown by withdrawal stress. They consumed alcohol even when it was contaminated with quinine. These data suggest the development of an addiction to the alcohol solutions.