Disseminated Tumor Cells and Dormancy in Breast Cancer Progression
Disseminated Tumor Cells and Dormancy in Breast Cancer Progression
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DOI：
10.1007/978-3-030-35805-1_3
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发表时间：
2020-01-01
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影响因子：
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通讯作者：
Fehm, Tanja
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文献类型：
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作者：
Banys-Paluchowski, Malgorzata;Reinhardt, Florian;Fehm, Tanja
单个癌细胞的血行播散是实体瘤患者的常见现象。这些细胞可能会经历不同的命运：大多数会在这个过程中死亡;一些会生长成转移，一些会在第二归巢位点持续多年，处于休眠状态。这种状态的机制仍然不清楚;单个癌细胞可以通过完全退出细胞周期或通过继续以缓慢的速度增殖而被细胞死亡抵消而存活。另一种假设认为，至少有一些休眠的肿瘤细胞具有干细胞样特征，这可能有助于它们极长的半衰期并增强化疗抗性。乳腺癌尤其以长期无临床疾病（有时长达20-30年）而闻名，随后是远处复发。在这一章中，我们探讨了肿瘤休眠的临床现象和播散的肿瘤细胞之间的关系，并讨论了治疗的潜在意义。
Hematogenous dissemination of single cancer cells is a common phenomenon in patients with solid tumors. These cells may experience different fates: most will die during the process; some will grow into metastasis and some will persist in secondary homing sites for many years in a state referred to as dormancy. The mechanisms of this state are still not clear; single cancer cells can survive either by completely withdrawing from the cell cycle or by continuing to proliferate at a slow rate that is counterbalanced by cell death. Another hypothesis assumes that at least some of dormant tumor cells feature stem cell-like characteristics that may contribute to their extremely long half-lives and enhance chemotherapy resistance. Breast cancer is particularly known for prolonged periods of clinical freedom of disease (sometimes up to 20-30 years), followed by a distant relapse. In this chapter, we explore the relationship between the clinical phenomenon of tumor dormancy and the disseminated tumor cells and discuss the potential implications for treatment.