TRANSPLANTED SUPRACHIASMATIC NUCLEUS DETERMINES CIRCADIAN PERIOD
TRANSPLANTED SUPRACHIASMATIC NUCLEUS DETERMINES CIRCADIAN PERIOD
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DOI：
10.1126/science.2305266
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发表时间：
1990-02-23
期刊：
影响因子：
56.9
通讯作者：
MENAKER, M
中科院分区：
文献类型：
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作者：
RALPH, MR;FOSTER, RG;MENAKER, M
用具有较短昼夜周期的突变仓鼠进行神经移植，验证了视交叉上核在哺乳动物昼夜节律系统中的起搏作用。来自视交叉上区的小神经移植物恢复了心律失常动物的昼夜节律，这些动物的核团已经被消融。恢复的节律总是表现出供体基因的周期，无论移植的方向或宿主的基因。因此，显性昼夜节律的基本周期由视交叉上区的细胞决定。
The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period. Small neural grafts from the suprachiasmatic region restored circadian rhythms to arrhythmic animals whose own nucleus had been ablated. The restored rhythms always exhibited the period of the donor genotype regardless of the direction of the transplant or genotype of the host. The basic period of the overt circadian rhythm therefore is determined by cells of the suprachiasmatic region.