In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons
In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons
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DOI：
10.1016/j.neuroscience.2019.08.014
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发表时间：
2019-11-01
期刊：
影响因子：
3.3
通讯作者：
Crowley, Nicole A.
中科院分区：
文献类型：
--
作者：
Dao, Nigel C.;Brockway, Dakota F.;Crowley, Nicole A.
生长抑素是一种神经肽，被认为在多种神经精神疾病中发挥作用，对健康衰老和行为弹性很重要。生长抑素肽能释放的生理条件尚不明确。利用转基因小鼠的光遗传学和生化方法的结合，我们展示了在小鼠急性脑切片中诱导和抑制生长抑素释放的实验。(c) 2019 ibroElsevier Ltd.出版。版权所有。
Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlying somatostatin peptidergic release are not well-defined. Using a combination of optogenetic and biochemical approaches in transgenic mice, we demonstrate an assay for the induction and inhibition of somatostatin release in mouse acute brain slices. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.