Defective regulation of vasopressin gene expression in Brattleboro rats.
Defective regulation of vasopressin gene expression in Brattleboro rats.
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布拉特尔伯勒大鼠中加压素基因表达的调节有缺陷。
DOI：
10.1152/ajpendo.1987.252.5.e637
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Emanuel,RL
中科院分区：
文献类型：
--
作者：
Majzoub,JA;Carrazana,EJ;Shulman,JS;Baker,KJ;Emanuel,RL
布拉特尔伯勒大鼠因常染色体隐性遗传而患有严重尿崩症，导致无法合成可检测量的下丘脑加压素。为了确定这种异常是否是由于 Brattleboro 大鼠加压素基因的调节缺陷所致，我们研究了正常 Long-Evans 和纯合 Brattleboro 大鼠在渗透压下下丘脑加压素 mRNA 含量的变化，并将这些变化与缺水的全身反应相关联。我们报告说，布拉特尔伯勒大鼠在加压素基因表达调节方面确实存在明显缺陷，包括无法增加下丘脑加压素 mRNA 含量以应对严重的渗透压。
The Brattleboro rat has severe diabetes insipidus due to an autosomal recessive trait resulting in the inability to synthesize detectable amounts of hypothalamic vasopressin. To determine whether this abnormality is due to a regulatory defect in the Brattleboro rat's vasopressin gene, we studied changes in the hypothalamic content of vasopressin mRNA in normal Long-Evans and homozygous Brattleboro rats subjected to osmotic stress and correlated these changes with systemic responses to water deprivation. We report that the Brattleboro rat does have a marked defect in the regulation of vasopressin gene expression consisting of an inability to increase hypothalamic vasopressin mRNA content in response to severe osmotic stress.