Bacteria and aetiology of cancer of large bowel.
Bacteria and aetiology of cancer of large bowel.
复制标题
大肠癌的细菌和病因学。
DOI：
10.1016/s0140-6736(71)90837-3
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发表时间：
1971
期刊：
影响因子：
168.9
通讯作者：
R.E.O. Williams
中科院分区：
文献类型：
--
作者：
M. Hill;B. Drasar;V. Aries;J. Crowther;G. Hawksworth;R.E.O. Williams
结肠癌发病率的地理差异似乎与饮食中脂肪含量的变化有关。据推测，肠道细菌可能能够从膳食脂肪或胆汁类固醇中产生致癌物，结肠癌发病率的变化可能部分取决于饮食差异引起的肠道细菌植物群组成的差异。研究人员对来自六个地区的面部样本进行了细菌和类固醇含量的检测。来自英国和美国的面孔，在结肠癌发病率高的地方，与发病率低的乌干达、南印度或日本的人相比，他们的类杆菌数量更高，肠球菌和其他需氧菌数量更低。来自“西方“国家的人的粪便比来自非洲和东方国家的人含有更高浓度的类固醇，类固醇也更容易降解。这一结果与肠道细菌可能与结肠癌有关的论点是一致的。
The geographical variations in the incidence of carcinoma of the colon seem to be correlated with variation in the fat content of the diet. It was postulated that intestinal bacteria might be able to produce carcinogens from dietary fats or from bile steroids, and that the variations in the incidence of colon cancer might depend partly on differences in the composition of the intestinal bacterial flora brought about by the differences in diet. Samples of faces from six areas were examined for their content of bacteria and steroids. Faces from people in Britain and the U.S.A., where the incidence of colon cancer is high, had higher counts ofBacteroidesand lower counts of enterococci and other aerobic bacteria than fæces from people in Uganda, South India, or Japan, where the incidence of the disease is low. Fæces from people in the " Western " countries contained higher concentrations of steroids than those from the African and Eastern countries, and the steroids were also more degraded. The results are consonant with the thesis that the intestinal bacteria may be ætiologically related to cancer of the colon.