Associations among body size across the life course, adult height and endometriosis
Associations among body size across the life course, adult height and endometriosis
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DOI：
10.1093/humrep/dex207
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发表时间：
2017-08-01
影响因子：
6.1
通讯作者：
Kvaskoff, M.
中科院分区：
文献类型：
--
作者：
Farland, L. V.;Missmer, S. A.;Kvaskoff, M.
研究问题：整个生命过程中的体型和成人身高与子宫内膜异位症相关吗？总结回答：子宫内膜异位症与儿童、青春期和成年期的偏瘦体型有关;成年后身高较高;坐高较高。已知：文献表明，成人体型和身高与子宫内膜异位症风险相关，但很少有研究调查体型在整个生命过程中的作用。研究设计、规模、持续时间：我们在E3 N（法国国家教育部妇女流行病学研究所）中采用了嵌套病例对照设计，这是一个前瞻性的法国妇女队列。每2-3年通过自填问卷更新一次数据。优势比（OR）和95%CI采用logistic回归模型计算，调整了先验的混杂因素。参与者/材料，设置，方法：在61208名纳入的妇女中，共有2416例子宫内膜异位症病例被报道为手术确诊。子宫内膜异位症的几率较低的妇女谁报告有一个大的与瘦的身体大小在8年（趋势P = 0.003），初潮（趋势P < 0.0001）和20-25岁（趋势P < 0.0001）。身高最高四分位数的女性与身高最低四分位数的女性（< 158 cm）相比，子宫内膜异位症的几率在统计学上显著增加（162-164 cm：OR = 1.28，95% CI = 1.12-1.46; >= 165 cm：OR = 1.33，95% CI = 1.18-1.49，趋势P < 0.0001）。在坐高的女性中也观察到统计学显著增加的几率（OR = 1.24，95%CI = 1.05-1.47，趋势P = 0.01）。腿长与子宫内膜异位症无统计学显著相关性。限制原因：子宫内膜异位症病例可能容易分类错误;然而，我们将病例定义限制为经病理证实的病例，这显示了较高的验证率。身体大小是基于回顾性自我报告，这可能是受召回bias.WIDER影响的调查结果：这项研究的结果表明，子宫内膜异位症是正相关的，在整个生命历程和总成人身高瘦体尺寸。他们还认为身高的组成部分与子宫内膜异位症有关，这应该进一步研究。
STUDY QUESTION: Are body size across the life course and adult height associated with endometriosis?SUMMARY ANSWER: Endometriosis is associated with lean body size during childhood, adolescence and adulthood; tall total adult height; and tall sitting height.WHAT IS KNOWN ALREADY: The literature suggests that both adult body size and height are associated with endometriosis risk, but few studies have investigated the role of body size across the life course. Additionally, no study has investigated the relationships between components of height and endometriosis.STUDY DESIGN, SIZE, DURATION: We used a nested case-control design within E3N (Etude Epidemiologique aupres de femmes de l'Education Nationale), a prospective cohort of French women. Data were updated every 2-3 years through self-administered questionnaires. Odds ratios (ORs) and 95% CIs were computed using logistic regression models adjusted for a priori confounding factors.PARTICIPANTS/MATERIALS, SETTING, METHODS: A total of 2416 endometriosis cases were reported as surgically ascertained among the 61 208 included women.MAIN RESULTS AND THE ROLE OF CHANCE: The odds of endometriosis were lower among women who reported having a large versus lean body size at 8 years (P for trend = 0.003), at menarche (P for trend < 0.0001) and at ages 20-25 years (P for trend < 0.0001). Women in the highest quartiles of height had statistically significantly increased odds of endometriosis compared to those in the lowest (< 158 cm) (162-164 cm: OR = 1.28, 95% CI = 1.12-1.46; >= 165 cm: OR = 1.33, 95% CI = 1.18-1.49, P for trend < 0.0001). Statistically significantly increased odds were also observed among women with a taller sitting height (OR = 1.24, 95% CI = 1.05-1.47, P for trend = 0.01). Leg length was not statistically significantly associated with endometriosis.LIMITATIONS REASONS FOR CAUTION: Endometriosis cases may be prone to misclassification; however, we restricted our case definition to surgically-confirmed cases, which showed a high validation rate. Body size is based on retrospective self-report, which may be subject to recall bias.WIDER IMPLICATIONS OF THE FINDINGS: The results of this study suggest that endometriosis is positively associated with lean body size across the life course and total adult height. They also suggest that components of height are associated with endometriosis, which should be investigated further.