Down-regulation of Long Non-coding RNA LINC01554 in Hepatocellular Cancer and its Clinical Significance
Down-regulation of Long Non-coding RNA LINC01554 in Hepatocellular Cancer and its Clinical Significance
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长链非编码RNA LINC01554在肝细胞癌中的下调及其临床意义
DOI：
10.7150/jca.40512
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发表时间：
2020-01-01
影响因子：
3.9
通讯作者：
Wang, Weilin
中科院分区：
文献类型：
--
作者：
Ding, Yuan;Sun, Zhongquan;Wang, Weilin
Background: For high morbidity rate but lack of early accurate screening, hepatocellular cancer (HCC) manifests as the fourth leading cause of cancer related death worldwide. Accumulating evidence demonstrated that a series of long noncoding RNA (lncRNA) have strong association with pathogenesis and clinical evaluation of HCC. LINC01554, one kind of lncRNA, has been found specifically enriched in liver tissue. However, the relationship between LINC01554 expression and HCC tumorigenesis remains unclear.Methods: The relative LINC01554 expression was measured in HCC tissues of 138 patients and several HCC cell lines using quantitative real-time PCR. Patients were grouped according to individual LINC01554 expression. Then, the potential association between LINC01554 expression in HCC tissues and clinical characteristics as well as prognostic information of patients was evaluated.Results: Compared to correspongding adjacent liver tissues, the LINC01554 expression in HCC was significantly down-regulated (P=0.001). And its expression levels in HCC cell lines were also remarkably lower than that in normal human hepatocyte cell line (P
