CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
复制标题
DOI：
10.1016/s1074-7613(00)80201-0
复制
发表时间：
2000-05-01
期刊：
影响因子：
32.4
通讯作者：
Lira, SA
中科院分区：
文献类型：
--
作者：
Cook, DN;Prosser, DM;Lira, SA
趋化因子引导的白细胞亚群的迁移可能是造成系统免疫和粘膜免疫之间质的差异的原因之一。在这里，我们证明在缺乏趋化因子受体CCR6的小鼠中，表达CD11c和CD11b的树突状细胞在Peyer‘s斑块的上皮下穹顶中缺失。这些小鼠对口服抗原和肠病病毒轮状病毒的体液免疫反应也受到损害。此外，CCR6(-/-)小鼠粘膜内特定T淋巴细胞群体的细胞数量增加了2倍至15倍，包括CD4(+)和CD8(+)α-β-TCRT细胞。相比之下，CCR6(-/-)小鼠对皮下抗原的全身免疫反应是正常的。这些发现表明，CCR6是肠粘膜中体液免疫和淋巴细胞动态平衡的粘膜特异性调节剂。
Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches. These mice also have an impaired humoral immune response to orally administered antigen and to the enteropathic virus rotavirus. In addition, CCR6(-/-) mice have a 2-fold to 15-fold increase in cells of select T lymphocyte populations within the mucosa, including CD4(+) and CD8(+) alpha beta-TCR T cells. By contrast, systemic immune responses to subcutaneous antigens in CCR6(-/-) mice are normal. These findings demonstrate that CCR6 is a mucosa-specific regulator of humoral immunity and lymphocyte homeostasis in the intestinal mucosa.