Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium.
Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium.
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DOI：
10.18388/abp.2003_3707
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发表时间：
2003
影响因子：
1.7
通讯作者：
E. Kowalczyk;A. Kopff;P. Fijałkowski;M. Kopff;J. Niedworok;J. Błaszczyk;J. Kȩdziora;P. Tyślerowicz
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文献类型：
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作者：
E. Kowalczyk;A. Kopff;P. Fijałkowski;M. Kopff;J. Niedworok;J. Błaszczyk;J. Kȩdziora;P. Tyślerowicz
镉是一种危险的职业和环境毒素。它在人体内蓄积，主要存在于肝脏和肾脏中。镉的半衰期约为10年，因此镉中毒的症状可能会在接触几年后出现。到目前为止，在用这种金属络合化合物治疗中毒时，已经使用了许多令人不快的症状。在我们的研究中，我们利用黑果紫罗兰中的花色苷来减轻镉的危害。与单纯染镉组比较，染镉组小鼠血清中天冬氨酸转氨酶(AST)和丙氨酸氨基转移酶(ALT)活性、血清胆红素和尿素浓度显著降低，肝、肾镉蓄积量减少。
Cadmium is a dangerous occupational and environmental toxin. It accumulates in the human organism mainly in liver and kidneys. Cadmium half-life is about 10 years, so the symptoms of cadmium intoxication may occur several years after the exposure. Until now in treating intoxication with this metal chelating compounds have been used, burdened with numerous undesirable symptoms. In our investigations anthocyanins from Aronia melanocarpa were used to reduce the harmful results caused by cadmium. Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only.