Effects of static interventions on disuse atrophy of the rat soleus muscle at different sites along its longitudinal axis.
Effects of static interventions on disuse atrophy of the rat soleus muscle at different sites along its longitudinal axis.
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DOI：
10.1589/jpts.27.2317
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发表时间：
2015-07
影响因子：
--
通讯作者：
Yamazaki T
中科院分区：
文献类型：
--
作者：
Miyachi R;Yamazaki T
[目的]验证静态干预（热负荷和肌肉拉伸）对比目鱼肌废用相关适应性变化的抑制作用，并在比目鱼肌纵轴沿着不同部位比较这些作用。[受试者] 40只8周龄雄性Wistar大鼠。[方法]通过测量大鼠比目鱼肌近端、中段和远端肌纤维的横截面积、琥珀酸脱氢酶活性和毛细血管数，评价热负荷和/或肌肉拉伸对大鼠后肢悬吊过程中比目鱼肌的影响。[结果]在无干预的情况下，近端区域横截面积减少最多，而远端区域琥珀酸脱氢酶活性和毛细血管数量减少最多。近端和远端区域之间的这些差异随着两种干预措施而减少，并且热负荷和肌肉拉伸的组合的效果最明显。[结论]后肢悬吊导致近端和远端区域肌肉结构差异增加，而热负荷和肌肉拉伸等静态干预可以抑制这种与肌肉废用相关的异质性。此外，热负荷和肌肉拉伸的组合最大程度地降低了异质性。
[Purpose] The purpose of our study was to verify the inhibitory effects of static intervention (heat load and muscle stretching) on disuse-related adaptation changes in the soleus muscle and to compare these effects across different sites along its longitudinal axis. [Subjects] Forty 8-week-old male Wistar rats. [Methods] The effects of heat load and/or muscle stretching in the rat soleus during hindlimb suspension were evaluated by measuring the cross-sectional area of the muscle fibers, succinate dehydrogenase activity, and number of capillaries in the proximal, middle, and distal regions. [Results] With no intervention the proximal region showed the highest reduction in the cross-sectional area, whereas the distal region showed the highest reduction in succinate dehydrogenase activity and the number of capillaries due to hindlimb suspension. These differences between the proximal and distal regions decreased with both interventions, and the effects were most pronounced with a combination of heat load and muscle stretching. [Conclusion] Differences in the muscle structure between the proximal and distal regions increased due to hindlimb suspension, and this heterogeneity associated with muscle disuse was inhibited by static intervention including heat load and muscle stretching. Furthermore, the combination of heat load and muscle stretching most reduced the heterogeneity.