Analysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays.
Analysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays.
复制标题
使用 cDNA 微阵列分析衰老和患病心肌中基因组表达谱的改变。
DOI：
10.1016/s1388-9842(02)00169-1
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Boheler,KennethR
中科院分区：
文献类型：
--
作者：
Juhasz,Ondrej;Zhu,Yi;Garg,Rahul;Anisimov,SergeyV;Boheler,KennethR
Cardiac function deteriorates with aging or disease. Short term, any changes in heart function may be beneficial, but long term the alterations are often detrimental. At a molecular level, functional adaptations involve quantitative and qualitative changes in gene expression. Analysis of all the RNA transcripts present in a cell's population (transcriptome) offers unprecedented opportunities to map these transitions. Microarrays (chips), capable of evaluating thousands of transcripts in one assay, are ideal for transcriptome analyses. Gene expression profiling provides information about the dynamics of total genome expression in response to environmental changes and may point to candidate genes responsible for the cascade of events that result in disease or are a consequence of aging. The aim of this review is to describe how comparisons of cellular transcriptomes by cDNA array based techniques provide information about the dynamics of total gene expression, and how the results can be applied to the study of cardiovascular disease and aging.
