Cell Internalizable and Intracellularly Degradable Cationic Polyurethane Micelles as a Potential Platform for Efficient Imaging and Drug Delivery
Cell Internalizable and Intracellularly Degradable Cationic Polyurethane Micelles as a Potential Platform for Efficient Imaging and Drug Delivery
复制标题
细胞内化和细胞内可降解的阳离子聚氨酯胶束作为有效成像和药物输送的潜在平台
DOI：
10.1021/bm500506v
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发表时间：
2014-08-01
影响因子：
6.2
通讯作者：
Fu, Qiang
中科院分区：
文献类型：
--
作者：
Ding, Mingming;Zeng, Xin;Fu, Qiang
一种细胞内化和细胞内可降解的胶束系统，由侧链上带有细胞穿透gemini季铵悬垂基团和主链上氧化还原反应二硫键的多块聚氨酯组成，用于潜在的磁共振成像（MRI）和药物输送。该纳米载体具有典型的“可切割核-可内化壳-保护电晕”结构，具有体积小、表面带正电荷、负载能力高、还原触发不稳定等特点。此外，它可以快速进入肿瘤细胞并根据细胞内水平的谷胱甘肽释放其货物，从而提高体外药物疗效。负载超顺磁性氧化铁（SPIO）纳米颗粒的磁性胶束表现出优异的MRI对比增强，发现T-2弛豫度受到胶束核心内SPIO簇状形貌的影响。具有良好的细胞相容性和无毒降解产物的多功能载体可作为抗癌药物的有效细胞内递送和治疗效果实时监测的有前途的治疗候选者。
A cell internalizable and intracellularly degradable micellar system, assembled from multiblock polyurethanes bearing cell-penetrating gemini quaternary ammonium pendent groups in the side chain and redox-responsive disulfide linkages throughout the backbone, was developed for potential magnetic resonance imaging (MRI) and drug delivery. The nanocarrier is featured as a typical "cleavable core-internalizable shell-protective corona" architecture, which exhibits small size, positive surface charge, high loading capacity, and reduction-triggered destabilization. Furthermore, it can rapidly enter tumor cells and release its cargo in response to an intracellular level of glutathione, resulting in enhanced drug efficacy in vitro. The magnetic micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles demonstrate excellent MRI contrast enhancement, with T-2 relaxivity found to be affected by the morphology of SPIO-clustering inside the micelle core. The multifunctional carrier with good cytocompatibility and nontoxic degradation products can serve as a promising theranostic candidate for efficient intracellular delivery of anticancer drugs and real-time monitoring of therapeutic effect.