CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation
CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation
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DOI：
10.1016/j.febslet.2006.05.021
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发表时间：
2006-06-12
期刊：
影响因子：
3.5
通讯作者：
Gotoh, Tomomi
中科院分区：
文献类型：
--
作者：
Tajiri, Seiji;Yano, Shigetoshi;Gotoh, Tomomi
神经营养因子对神经元的存活至关重要。我们发现，内质网（ER）应激-C/EBP同系物蛋白（CHOP）途径被激活在神经营养因子剥夺诱导的PC 12神经元细胞和原代培养的神经元的凋亡，这种凋亡被抑制在chop（-/-）小鼠的神经元。此外，我们发现CHOP在年轻成年小鼠的脑室下区（SVZ）和纹状体中表达。chop（-/-）小鼠SVZ中的凋亡细胞数量减少。这些结果表明ER应激-CHOP通路在脑发育过程中的神经元凋亡中起作用。(c)2006年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Neurotrophic factors are essential for the survival of neurons. We found that the endoplasmic reticulum (ER) stress-C/EBP homologues protein (CHOP) pathway to be activated during neurotrophic factor deprivation-induced apoptosis in PC12 neuronal cells and in primary cultured neurons, and this apoptosis was suppressed in the neurons from chop(-/-) mice. In addition, we found that CHOP is expressed in the subventricular zone (SVZ) and striatum of the young adult mouse brain. The number of apoptotic cells in the SVZ decreased in chop(-/-) mice. These results indicate that the ER stress-CHOP pathway plays a role in neuronal apoptosis during the development of the brain. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.