α-Linolenic acid is associated with MRI activity in a prospective cohort of multiple sclerosis patients
α-Linolenic acid is associated with MRI activity in a prospective cohort of multiple sclerosis patients
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DOI：
10.1177/1352458518779925
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发表时间：
2019-06-01
影响因子：
5.8
通讯作者：
Torkildsen, Oivind
中科院分区：
文献类型：
--
作者：
Bjornevik, Kjetil;Myhr, Kjell-Morten;Torkildsen, Oivind
背景：植物性 omega-3 脂肪酸 α-亚麻酸 (ALA) 与降低多发性硬化症风险相关。目前尚不清楚 ALA 是否影响疾病活动。目的：探讨 ALA 水平与疾病活动度之间的关联。方法：我们进行了一项队列研究，纳入了 87 名多发性硬化症 (MS) 患者，他们最初参加了 omega-3 脂肪酸随机试验（OFAMS 研究）。我们在随访期间测量了 ALA 的血清水平，并使用随机截距逻辑回归来估计 ALA 水平、新的磁共振成像 (MRI) 病变、扩展残疾状态量表 (EDSS) 进展和新复发之间的关联的比值比 (OR) 和 95% 置信区间 (CI)，并根据纳入时的年龄、性别和干扰素 β-1a 的使用进行调整。结果：在连续（每增加 1-SD）多变量调整分析中，较高的 ALA 水平与随访期间新发 T2 病变的较低几率显着相关（OR：0.59，95% CI：0.37-0.95）。新 T1Gd + 病变（OR：0.73，95% CI：0.48-1.11）、EDSS 进展（OR：0.62，95% CI：0.34-1.16）和新复发（OR：0.49，95% CI：0.22-1.10）的效果估计相似，但这些估计未达到统计学显着性。对维生素 D 和烟草使用的进一步调整并未对结果产生实质性改变。结论：我们发现 MS 患者的 ALA 水平较高与疾病活动度较低相关。
Background: The plant-based omega-3 fatty acid alpha-linolenic acid (ALA) has been associated with lower MS risk. It is currently unknown whether ALA affects disease activity. Objective: To investigate the association between ALA levels and disease activity. Methods: We conducted a cohort study including 87 multiple sclerosis (MS)-patients who originally participated in a randomized trial of omega-3 fatty acids (the OFAMS study). We measured serum levels of ALA during follow-up and used random intercept logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association between ALA levels, new magnetic resonance imaging (MRI) lesions, Expanded Disability Status Scale (EDSS) progression and new relapses adjusting for age at inclusion, sex, and use of interferon beta-1a. Results: In continuous (per 1-SD increase) multivariable-adjusted analyses, higher ALA levels were significantly associated with lower odds of new T2-lesions (OR: 0.59, 95% CI: 0.37-0.95) during follow-up. The effect estimates were similar for new T1Gd + lesions (OR: 0.73, 95% CI: 0.48-1.11), EDSS-progression (OR: 0.62, 95% CI: 0.34-1.16) and new relapses (OR: 0.49, 95% CI: 0.22-1.10), but these estimates did not reach statistical significance. Further adjustment for vitamin D and tobacco use did not materially change the results. Conclusion: We found that higher levels of ALA were associated with lower disease activity in MS-patients.