LOWER DEGREE OF ESTERIFICATION OF SERUM-CHOLESTEROL IN DEPRESSION - RELEVANCE FOR DEPRESSION AND SUICIDE RESEARCH
LOWER DEGREE OF ESTERIFICATION OF SERUM-CHOLESTEROL IN DEPRESSION - RELEVANCE FOR DEPRESSION AND SUICIDE RESEARCH
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DOI：
10.1111/j.1600-0447.1994.tb01589.x
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发表时间：
1994-10-01
影响因子：
6.7
通讯作者：
COSYNS, P
中科院分区：
文献类型：
--
作者：
MAES, M;DELANGHE, J;COSYNS, P
先前的研究表明，抑郁症和自杀与血清总胆固醇浓度的变化有关，并且在重度抑郁症中结合珠蛋白（Hp）表型的分布改变表明16号染色体上的变异可能与该疾病有关。LCAT：胆固醇酰基转移酶（LCAT，EC 2.3.1.43），催化血清中胆固醇的降解反应的酶，位于Hp基因附近。本研究检测了26名健康对照者、47名单相抑郁症患者（16名轻度抑郁症患者、14名单纯重度抑郁症患者和17名抑郁症患者）和12名抑郁症患者亲属的血清总胆固醇、游离胆固醇和酯化胆固醇比值。抑郁症受试者（无论亚型）和抑郁症受试者的亲属有一个显着较低的酯化胆固醇比比正常对照组。上述研究组之间的总胆固醇或游离胆固醇浓度无显著差异。在抑郁症受试者中，酯化胆固醇比率、总胆固醇或游离胆固醇与地塞米松后促肾上腺皮质激素或皮质醇值、Hp表型、疾病严重程度或自杀症状之间无显著关系。据推测，较低的酯化血清胆固醇可能构成一个脆弱的因素，抑郁症通过改变细胞膜微粘度。
Previous studies have suggested that depression and suicide are related to alterations in total cholesterol serum concentrations, and that an altered distribution of haptoglobin (Hp) phenotypes in major depression indicates that variation on chromosome 16 may be associated with that illness. Lecithin:cholesterol acyl transferase (LCAT, EC 2.3.1.43), the enzyme that catalyzes the esterifying reaction of cholesterol in serum, is located close to the Hp gene. This study examined the serum concentrations of total and free cholesterol and the esterified cholesterol ratio in 26 healthy controls, 47 unipolar depressed subjects (16 minor, 14 simple major and 17 melancholic depressed subjects) and 12 relatives of melancholic subjects. Depressed subjects (regardless of subtype) and relatives of depressed subjects had a significantly lower esterified cholesterol ratio than normal controls. No significant differences in total or free cholesterol concentrations were found between the above study groups. In depressed subjects, there were no significant relationships between the esterified cholesterol ratio, total or free cholesterol and postdexamethasone adrenocorticotropic or cortisol values, Hp phenotypes, severity of illness or suicidal symptoms. It is hypothesized that lower esterification in serum cholesterol may constitute a vulnerability factor for depression through alterations in cell membrane microviscosity.